A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.
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Auteurs principaux: | Alisa A. Garaeva, Albert Guskov, Dirk J. Slotboom, Cristina Paulino |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
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Sujets: | |
Accès en ligne: | https://doaj.org/article/ecaafebc4c2640a4ad0f1aaa6f025884 |
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