[53] Neutrophil-to-lymphocyte ratio in non-muscle-invasive bladder cancer
Objective: To evaluate the value of the neutrophil-to lymphocyte ratio (NLR) in non-muscle-invasive bladder cancer (NMIBC) with different prognostic factors and with the risk of progression and recurrence of this neoplasm. The NLR has been recognised as a prognostic factor for multiple cancers as a...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Taylor & Francis Group
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ecace6db0bb141498b6979919f3b6d3a |
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| Sumario: | Objective: To evaluate the value of the neutrophil-to lymphocyte ratio (NLR) in non-muscle-invasive bladder cancer (NMIBC) with different prognostic factors and with the risk of progression and recurrence of this neoplasm. The NLR has been recognised as a prognostic factor for multiple cancers as a systemic inflammatory response marker. Methods: Retrospective analysis of 103 patients diagnosed with high-grade NMIBC treated by transurethral resection of the tumour plus adjuvant bacille Calmette–Guérin (BCG). Epidemiological data analysed included: gender, age, smoking habits, other neoplasms. Tumour data analysed included: size, stage, pattern, number, association with carcinoma in situ (CIS), and treatment-related effects. NLR was calculated based on a 30-day pre-transurethral resection blood sample. Statistical analysis included chi-squared test, Kaplan–Meier, and uni- and multivariate Cox regression analyses. Results: In all, 97 patients (94.7%) were men, 53 were aged ⩾70 years (51.5%) and 63 were smokers (61.2%). Overall, 85 (82.5%) were primary tumours, 62 (60.2%) were single, 65 (63.1%) were >3 cm, 68 (66%) were stage T1, and 87 (84.5%) were associated with CIS. The main BCG-related side-effect was irritative voiding symptoms in 19.4% of the patients. In all, 30.1% of the patients had a NLR of ⩾2.5, with a median (interquartile range [IQR)] of 2 (1.47–2.71). The median (IQR) follow-up was 40 (19–81.5) months. A NLR of ⩾2.5 was significantly related with smoking habits (P = 0.003). None of the other factors assessed showed any statistical significance. The 5-year recurrence-free survival for a NLR of <2.5 was 80% and for a NLR of ⩾2.5 was 75%, without statistical significance. On uni- and multivariate Cox regression analyses a NLR of ⩾2.5 was not a predictive factor for recurrence of high-grade NMIBC or progression. Conclusion: In our study NLR failed to show its value as an independent prognostic factor for progression and recurrence in NMIBC. A threshold NLR value of 2.5 was statistically significant in those patients with smoking habits. |
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