A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging

Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool which allows the specific detection of metabolites that contain exchangeable amide, amine, and hydroxyl protons. Decades of development have progressed CEST imaging from an initial concept to a clinical imaging to...

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Autores principales:	Tianxin Gao, Chuyue Zou, Yifan Li, Zhenqi Jiang, Xiaoying Tang, Xiaolei Song
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chemical exchange saturation transfer body tumor clinical scanner amide proton transfer Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ecaddf9232be4561ab9bbb006405cd08
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spelling	oai:doaj.org-article:ecaddf9232be4561ab9bbb006405cd082021-11-11T17:02:34ZA Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging10.3390/ijms2221115591422-00671661-6596https://doaj.org/article/ecaddf9232be4561ab9bbb006405cd082021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11559https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool which allows the specific detection of metabolites that contain exchangeable amide, amine, and hydroxyl protons. Decades of development have progressed CEST imaging from an initial concept to a clinical imaging tool that is used to assess tumor metabolism. The first translation efforts involved brain imaging, but this has now progressed to imaging other body tissues. In this review, we summarize studies using CEST MRI to image a range of tumor types, including breast cancer, pelvic tumors, digestive tumors, and lung cancer. Approximately two thirds of the published studies involved breast or pelvic tumors which are sites that are less affected by body motion. Most studies conclude that CEST shows good potential for the differentiation of malignant from benign lesions with a number of reports now extending to compare different histological classifications along with the effects of anti-cancer treatments. Despite CEST being a unique ‘label-free’ approach with a higher sensitivity than MR spectroscopy, there are still some obstacles for implementing its clinical use. Future research is now focused on overcoming these challenges. Vigorous ongoing development and further clinical trials are expected to see CEST technology become more widely implemented as a mainstream imaging technology.Tianxin GaoChuyue ZouYifan LiZhenqi JiangXiaoying TangXiaolei SongMDPI AGarticlechemical exchange saturation transferbody tumorclinical scanneramide proton transferBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11559, p 11559 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemical exchange saturation transfer body tumor clinical scanner amide proton transfer Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	chemical exchange saturation transfer body tumor clinical scanner amide proton transfer Biology (General) QH301-705.5 Chemistry QD1-999 Tianxin Gao Chuyue Zou Yifan Li Zhenqi Jiang Xiaoying Tang Xiaolei Song A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
description	Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool which allows the specific detection of metabolites that contain exchangeable amide, amine, and hydroxyl protons. Decades of development have progressed CEST imaging from an initial concept to a clinical imaging tool that is used to assess tumor metabolism. The first translation efforts involved brain imaging, but this has now progressed to imaging other body tissues. In this review, we summarize studies using CEST MRI to image a range of tumor types, including breast cancer, pelvic tumors, digestive tumors, and lung cancer. Approximately two thirds of the published studies involved breast or pelvic tumors which are sites that are less affected by body motion. Most studies conclude that CEST shows good potential for the differentiation of malignant from benign lesions with a number of reports now extending to compare different histological classifications along with the effects of anti-cancer treatments. Despite CEST being a unique ‘label-free’ approach with a higher sensitivity than MR spectroscopy, there are still some obstacles for implementing its clinical use. Future research is now focused on overcoming these challenges. Vigorous ongoing development and further clinical trials are expected to see CEST technology become more widely implemented as a mainstream imaging technology.
format	article
author	Tianxin Gao Chuyue Zou Yifan Li Zhenqi Jiang Xiaoying Tang Xiaolei Song
author_facet	Tianxin Gao Chuyue Zou Yifan Li Zhenqi Jiang Xiaoying Tang Xiaolei Song
author_sort	Tianxin Gao
title	A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
title_short	A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
title_full	A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
title_fullStr	A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
title_full_unstemmed	A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging
title_sort	brief history and future prospects of cest mri in clinical non-brain tumor imaging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ecaddf9232be4561ab9bbb006405cd08
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A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging

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