Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.

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Autores principales:	Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecae75cc636546cf9e7e85d311c81677
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spelling	oai:doaj.org-article:ecae75cc636546cf9e7e85d311c816772021-12-02T16:50:12ZDedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria10.1038/s41467-018-05007-92041-1723https://doaj.org/article/ecae75cc636546cf9e7e85d311c816772018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05007-9https://doaj.org/toc/2041-1723G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.Zbigniew PietrasMagdalena A. WojcikLukasz S. BorowskiMaciej SzewczykTomasz M. KulinskiDominik CysewskiPiotr P. StepienAndrzej DziembowskiRoman J. SzczesnyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
description	G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.
format	article
author	Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny
author_facet	Zbigniew Pietras Magdalena A. Wojcik Lukasz S. Borowski Maciej Szewczyk Tomasz M. Kulinski Dominik Cysewski Piotr P. Stepien Andrzej Dziembowski Roman J. Szczesny
author_sort	Zbigniew Pietras
title	Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
title_short	Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
title_full	Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
title_fullStr	Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
title_full_unstemmed	Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
title_sort	dedicated surveillance mechanism controls g-quadruplex forming non-coding rnas in human mitochondria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ecae75cc636546cf9e7e85d311c81677
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Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

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