Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.
Guardado en:
Autores principales: | Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/ecae75cc636546cf9e7e85d311c81677 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
por: Seweryn Mroczek, et al.
Publicado: (2017) -
Dedicated Poster Abstracts
por: Gill Phillips
Publicado: (2019) -
Dedicated Poster Abstracts
por: Heather Hickey
Publicado: (2020) -
Studies on Energy Consumption of Electric Light Commercial Vehicle Powered by In-Wheel Drive Modules
por: Piotr Szewczyk, et al.
Publicado: (2021) -
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
por: Shawn M. Lyons, et al.
Publicado: (2017)