The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer

Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease—colorectal cancer (CRC). In this review,...

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Auteurs principaux:	Patrycja Kłos, Siarhei A. Dabravolski
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	inflammatory bowel diseases colorectal cancer chronic inflammation mitochondrial dysfunction mitochondrial mutations Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/ecaee7f5b98844a1b34dc770511b564e
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spelling	oai:doaj.org-article:ecaee7f5b98844a1b34dc770511b564e2021-11-11T17:08:30ZThe Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer10.3390/ijms2221116731422-00671661-6596https://doaj.org/article/ecaee7f5b98844a1b34dc770511b564e2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11673https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease—colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed.Patrycja KłosSiarhei A. DabravolskiMDPI AGarticleinflammatory bowel diseasescolorectal cancerchronic inflammationmitochondrial dysfunctionmitochondrial mutationsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11673, p 11673 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel diseases colorectal cancer chronic inflammation mitochondrial dysfunction mitochondrial mutations Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	inflammatory bowel diseases colorectal cancer chronic inflammation mitochondrial dysfunction mitochondrial mutations Biology (General) QH301-705.5 Chemistry QD1-999 Patrycja Kłos Siarhei A. Dabravolski The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
description	Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease—colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed.
format	article
author	Patrycja Kłos Siarhei A. Dabravolski
author_facet	Patrycja Kłos Siarhei A. Dabravolski
author_sort	Patrycja Kłos
title	The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
title_short	The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
title_full	The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
title_fullStr	The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
title_full_unstemmed	The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
title_sort	role of mitochondria dysfunction in inflammatory bowel diseases and colorectal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ecaee7f5b98844a1b34dc770511b564e
work_keys_str_mv	AT patrycjakłos theroleofmitochondriadysfunctionininflammatoryboweldiseasesandcolorectalcancer AT siarheiadabravolski theroleofmitochondriadysfunctionininflammatoryboweldiseasesandcolorectalcancer AT patrycjakłos roleofmitochondriadysfunctionininflammatoryboweldiseasesandcolorectalcancer AT siarheiadabravolski roleofmitochondriadysfunctionininflammatoryboweldiseasesandcolorectalcancer
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The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer

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