Tumor diversity and the trade-off between universal cancer tasks

The evolutionary trade-offs faced by tumors are poorly understood, yet could contribute to the molecular diversity of cancer. Here, the authors analyze the diversity of genetic alterations, genes expressed and drug sensitivities among solid tumors to explore what evolutionary trade-offs may explain...

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Autores principales:	Jean Hausser, Pablo Szekely, Noam Bar, Anat Zimmer, Hila Sheftel, Carlos Caldas, Uri Alon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecaf089d1dd645f5a7d083948b766c14
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spelling	oai:doaj.org-article:ecaf089d1dd645f5a7d083948b766c142021-12-02T15:35:05ZTumor diversity and the trade-off between universal cancer tasks10.1038/s41467-019-13195-12041-1723https://doaj.org/article/ecaf089d1dd645f5a7d083948b766c142019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13195-1https://doaj.org/toc/2041-1723The evolutionary trade-offs faced by tumors are poorly understood, yet could contribute to the molecular diversity of cancer. Here, the authors analyze the diversity of genetic alterations, genes expressed and drug sensitivities among solid tumors to explore what evolutionary trade-offs may explain the molecular diversity of tumors.Jean HausserPablo SzekelyNoam BarAnat ZimmerHila SheftelCarlos CaldasUri AlonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean Hausser Pablo Szekely Noam Bar Anat Zimmer Hila Sheftel Carlos Caldas Uri Alon Tumor diversity and the trade-off between universal cancer tasks
description	The evolutionary trade-offs faced by tumors are poorly understood, yet could contribute to the molecular diversity of cancer. Here, the authors analyze the diversity of genetic alterations, genes expressed and drug sensitivities among solid tumors to explore what evolutionary trade-offs may explain the molecular diversity of tumors.
format	article
author	Jean Hausser Pablo Szekely Noam Bar Anat Zimmer Hila Sheftel Carlos Caldas Uri Alon
author_facet	Jean Hausser Pablo Szekely Noam Bar Anat Zimmer Hila Sheftel Carlos Caldas Uri Alon
author_sort	Jean Hausser
title	Tumor diversity and the trade-off between universal cancer tasks
title_short	Tumor diversity and the trade-off between universal cancer tasks
title_full	Tumor diversity and the trade-off between universal cancer tasks
title_fullStr	Tumor diversity and the trade-off between universal cancer tasks
title_full_unstemmed	Tumor diversity and the trade-off between universal cancer tasks
title_sort	tumor diversity and the trade-off between universal cancer tasks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ecaf089d1dd645f5a7d083948b766c14
work_keys_str_mv	AT jeanhausser tumordiversityandthetradeoffbetweenuniversalcancertasks AT pabloszekely tumordiversityandthetradeoffbetweenuniversalcancertasks AT noambar tumordiversityandthetradeoffbetweenuniversalcancertasks AT anatzimmer tumordiversityandthetradeoffbetweenuniversalcancertasks AT hilasheftel tumordiversityandthetradeoffbetweenuniversalcancertasks AT carloscaldas tumordiversityandthetradeoffbetweenuniversalcancertasks AT urialon tumordiversityandthetradeoffbetweenuniversalcancertasks
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Tumor diversity and the trade-off between universal cancer tasks

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