Crosstalk between CST and RPA regulates RAD51 activity during replication stress

During replication stress, the RPA protein complex coats single-stranded DNA to preclude RAD51 loading. Here, the authors show how RPA and CST crosstalk to regulate RAD51 activity.

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Bibliographic Details
Main Authors: Kai-Hang Lei, Han-Lin Yang, Hao-Yen Chang, Hsin-Yi Yeh, Dinh Duc Nguyen, Tzu-Yu Lee, Xinxing Lyu, Megan Chastain, Weihang Chai, Hung-Wen Li, Peter Chi
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/ecb6eb4b3da245efbbff43e501310a5d
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Summary:During replication stress, the RPA protein complex coats single-stranded DNA to preclude RAD51 loading. Here, the authors show how RPA and CST crosstalk to regulate RAD51 activity.