CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination.

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination.

<h4>Background</h4>Although CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consistin...

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Autores principales: Tara Elvang, Jan P Christensen, Rolf Billeskov, Truc Thi Kim Thanh Hoang, Peter Holst, Allan Randrup Thomsen, Peter Andersen, Jes Dietrich
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/ecc6ac10cb574f90b990bfc1e5903c8b
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