Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protecti...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wenqian He, Chi-Jene Chen, Caitlin E. Mullarkey, Jennifer R. Hamilton, Christine K. Wong, Paul E. Leon, Melissa B. Uccellini, Veronika Chromikova, Carole Henry, Kevin W. Hoffman, Jean K. Lim, Patrick C. Wilson, Matthew S. Miller, Florian Krammer, Peter Palese, Gene S. Tan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/ecc73d871ca24888b8f3af7ce766d50b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection.