Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protecti...

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Autores principales:	Wenqian He, Chi-Jene Chen, Caitlin E. Mullarkey, Jennifer R. Hamilton, Christine K. Wong, Paul E. Leon, Melissa B. Uccellini, Veronika Chromikova, Carole Henry, Kevin W. Hoffman, Jean K. Lim, Patrick C. Wilson, Matthew S. Miller, Florian Krammer, Peter Palese, Gene S. Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecc73d871ca24888b8f3af7ce766d50b
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spelling	oai:doaj.org-article:ecc73d871ca24888b8f3af7ce766d50b2021-12-02T15:38:57ZAlveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice10.1038/s41467-017-00928-32041-1723https://doaj.org/article/ecc73d871ca24888b8f3af7ce766d50b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00928-3https://doaj.org/toc/2041-1723Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection.Wenqian HeChi-Jene ChenCaitlin E. MullarkeyJennifer R. HamiltonChristine K. WongPaul E. LeonMelissa B. UccelliniVeronika ChromikovaCarole HenryKevin W. HoffmanJean K. LimPatrick C. WilsonMatthew S. MillerFlorian KrammerPeter PaleseGene S. TanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
description	Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection.
format	article
author	Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan
author_facet	Wenqian He Chi-Jene Chen Caitlin E. Mullarkey Jennifer R. Hamilton Christine K. Wong Paul E. Leon Melissa B. Uccellini Veronika Chromikova Carole Henry Kevin W. Hoffman Jean K. Lim Patrick C. Wilson Matthew S. Miller Florian Krammer Peter Palese Gene S. Tan
author_sort	Wenqian He
title	Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
title_short	Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
title_full	Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
title_fullStr	Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
title_full_unstemmed	Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
title_sort	alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza a virus in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ecc73d871ca24888b8f3af7ce766d50b
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Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

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