Reactivity in the human retinal microvasculature measured during acute gas breathing provocations

Abstract Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3–25 µm diameter vessels of the human...

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Autores principales:	Angelina Duan, Phillip A. Bedggood, Andrew B. Metha, Bang V. Bui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ecc79ed6ce64478f8e1c1d30d80aaeaf
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spelling	oai:doaj.org-article:ecc79ed6ce64478f8e1c1d30d80aaeaf2021-12-02T16:08:23ZReactivity in the human retinal microvasculature measured during acute gas breathing provocations10.1038/s41598-017-02344-52045-2322https://doaj.org/article/ecc79ed6ce64478f8e1c1d30d80aaeaf2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02344-5https://doaj.org/toc/2045-2322Abstract Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3–25 µm diameter vessels of the human inner retinal circulation and monitored the effects of altered gas-breathing conditions. During isocapnic hyperoxia, definite constrictions were seen in 51% of vessel segments (mean ± SD for pre-capillary arterioles −9.5 ± 3.0%; capillaries −11.8 ± 3.3%; post-capillary venules −6.3 ± 2.8%); these are comparable with responses previously reported in larger vessels. During isoxic hypercapnia, definite dilations were seen in 47% of vessel segments (mean ± SD for pre-capillary arterioles +9.8 ± 1.5%; capillaries +13.7 ± 3.8%; post-capillary venules +7.5 ± 4.2%); these are proportionally greater than responses previously reported in larger vessels. The magnitude of these proportional changes implies that the capillary beds themselves play an important role in the retinal response to changes in carbon dioxide levels. Interestingly, the distribution of microvascular responses shown here differs from our previously reported responses to flicker stimulation, suggesting differences in the way blood supply is coordinated following gas perturbation and altered neural activity.Angelina DuanPhillip A. BedggoodAndrew B. MethaBang V. BuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelina Duan Phillip A. Bedggood Andrew B. Metha Bang V. Bui Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
description	Abstract Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3–25 µm diameter vessels of the human inner retinal circulation and monitored the effects of altered gas-breathing conditions. During isocapnic hyperoxia, definite constrictions were seen in 51% of vessel segments (mean ± SD for pre-capillary arterioles −9.5 ± 3.0%; capillaries −11.8 ± 3.3%; post-capillary venules −6.3 ± 2.8%); these are comparable with responses previously reported in larger vessels. During isoxic hypercapnia, definite dilations were seen in 47% of vessel segments (mean ± SD for pre-capillary arterioles +9.8 ± 1.5%; capillaries +13.7 ± 3.8%; post-capillary venules +7.5 ± 4.2%); these are proportionally greater than responses previously reported in larger vessels. The magnitude of these proportional changes implies that the capillary beds themselves play an important role in the retinal response to changes in carbon dioxide levels. Interestingly, the distribution of microvascular responses shown here differs from our previously reported responses to flicker stimulation, suggesting differences in the way blood supply is coordinated following gas perturbation and altered neural activity.
format	article
author	Angelina Duan Phillip A. Bedggood Andrew B. Metha Bang V. Bui
author_facet	Angelina Duan Phillip A. Bedggood Andrew B. Metha Bang V. Bui
author_sort	Angelina Duan
title	Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
title_short	Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
title_full	Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
title_fullStr	Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
title_full_unstemmed	Reactivity in the human retinal microvasculature measured during acute gas breathing provocations
title_sort	reactivity in the human retinal microvasculature measured during acute gas breathing provocations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ecc79ed6ce64478f8e1c1d30d80aaeaf
work_keys_str_mv	AT angelinaduan reactivityinthehumanretinalmicrovasculaturemeasuredduringacutegasbreathingprovocations AT phillipabedggood reactivityinthehumanretinalmicrovasculaturemeasuredduringacutegasbreathingprovocations AT andrewbmetha reactivityinthehumanretinalmicrovasculaturemeasuredduringacutegasbreathingprovocations AT bangvbui reactivityinthehumanretinalmicrovasculaturemeasuredduringacutegasbreathingprovocations
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Reactivity in the human retinal microvasculature measured during acute gas breathing provocations

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