Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinical models and identify vulnerabilities that could...
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Nature Portfolio
2018
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oai:doaj.org-article:ecc83cf960564bd2938fc055d45d8a012021-12-02T16:56:59ZTargetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models10.1038/s41467-018-04356-92041-1723https://doaj.org/article/ecc83cf960564bd2938fc055d45d8a012018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04356-9https://doaj.org/toc/2041-1723T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinical models and identify vulnerabilities that could be further exploited to treat patients afflicted by these diseases.Samuel Y. NgNoriaki YoshidaAmanda L. ChristieMahmoud GhandiNeekesh V. DhariaJoshua DempsterMark MurakamiKay ShigemoriSara N. MorrowAlexandria Van ScoykNicolas A. CorderoKristen E. StevensonManeka PuligandlaBrian HaasChristopher LoRobin MeyersGalen GaoAndrew CherniackAbner LouissaintValentina NardiAaron R. ThornerHenry LongXintao QiuElizabeth A. MorganDavid M. DorfmanDanilo FioreJulie JangAlan L. EpsteinAhmet DoganYanming ZhangSteven M. HorwitzEric D. JacobsenSolimar SantiagoJian-Guo RenVincent GuerlavaisD. Allen AnnisManuel AivadoMansoor N. SalehAmitkumar MehtaAviad TsherniakDavid RootFrancisca VazquezWilliam C. HahnGiorgio InghiramiJon C. AsterDavid M. WeinstockRaphael KochNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Samuel Y. Ng Noriaki Yoshida Amanda L. Christie Mahmoud Ghandi Neekesh V. Dharia Joshua Dempster Mark Murakami Kay Shigemori Sara N. Morrow Alexandria Van Scoyk Nicolas A. Cordero Kristen E. Stevenson Maneka Puligandla Brian Haas Christopher Lo Robin Meyers Galen Gao Andrew Cherniack Abner Louissaint Valentina Nardi Aaron R. Thorner Henry Long Xintao Qiu Elizabeth A. Morgan David M. Dorfman Danilo Fiore Julie Jang Alan L. Epstein Ahmet Dogan Yanming Zhang Steven M. Horwitz Eric D. Jacobsen Solimar Santiago Jian-Guo Ren Vincent Guerlavais D. Allen Annis Manuel Aivado Mansoor N. Saleh Amitkumar Mehta Aviad Tsherniak David Root Francisca Vazquez William C. Hahn Giorgio Inghirami Jon C. Aster David M. Weinstock Raphael Koch Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| description |
T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinical models and identify vulnerabilities that could be further exploited to treat patients afflicted by these diseases. |
| format |
article |
| author |
Samuel Y. Ng Noriaki Yoshida Amanda L. Christie Mahmoud Ghandi Neekesh V. Dharia Joshua Dempster Mark Murakami Kay Shigemori Sara N. Morrow Alexandria Van Scoyk Nicolas A. Cordero Kristen E. Stevenson Maneka Puligandla Brian Haas Christopher Lo Robin Meyers Galen Gao Andrew Cherniack Abner Louissaint Valentina Nardi Aaron R. Thorner Henry Long Xintao Qiu Elizabeth A. Morgan David M. Dorfman Danilo Fiore Julie Jang Alan L. Epstein Ahmet Dogan Yanming Zhang Steven M. Horwitz Eric D. Jacobsen Solimar Santiago Jian-Guo Ren Vincent Guerlavais D. Allen Annis Manuel Aivado Mansoor N. Saleh Amitkumar Mehta Aviad Tsherniak David Root Francisca Vazquez William C. Hahn Giorgio Inghirami Jon C. Aster David M. Weinstock Raphael Koch |
| author_facet |
Samuel Y. Ng Noriaki Yoshida Amanda L. Christie Mahmoud Ghandi Neekesh V. Dharia Joshua Dempster Mark Murakami Kay Shigemori Sara N. Morrow Alexandria Van Scoyk Nicolas A. Cordero Kristen E. Stevenson Maneka Puligandla Brian Haas Christopher Lo Robin Meyers Galen Gao Andrew Cherniack Abner Louissaint Valentina Nardi Aaron R. Thorner Henry Long Xintao Qiu Elizabeth A. Morgan David M. Dorfman Danilo Fiore Julie Jang Alan L. Epstein Ahmet Dogan Yanming Zhang Steven M. Horwitz Eric D. Jacobsen Solimar Santiago Jian-Guo Ren Vincent Guerlavais D. Allen Annis Manuel Aivado Mansoor N. Saleh Amitkumar Mehta Aviad Tsherniak David Root Francisca Vazquez William C. Hahn Giorgio Inghirami Jon C. Aster David M. Weinstock Raphael Koch |
| author_sort |
Samuel Y. Ng |
| title |
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| title_short |
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| title_full |
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| title_fullStr |
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| title_full_unstemmed |
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models |
| title_sort |
targetable vulnerabilities in t- and nk-cell lymphomas identified through preclinical models |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ecc83cf960564bd2938fc055d45d8a01 |
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