One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.

<h4>Purpose</h4>To compare the safety and efficacy of microshunt implantation augmented with Mitomycin C in patients with pseudoexfoliation glaucoma (PEXG) and primary open-angle glaucoma (POAG).<h4>Methods</h4>In this retrospective, single centre, interventional study, 46 ey...

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Autores principales:	Matthias Nobl, Sigrid Freissinger, Stefan Kassumeh, Siegfried Priglinger, Marc J Mackert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ecca88d6b9fa46fd970704a2d5de84cb
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spelling	oai:doaj.org-article:ecca88d6b9fa46fd970704a2d5de84cb2021-12-02T20:19:25ZOne-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.1932-620310.1371/journal.pone.0256670https://doaj.org/article/ecca88d6b9fa46fd970704a2d5de84cb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256670https://doaj.org/toc/1932-6203<h4>Purpose</h4>To compare the safety and efficacy of microshunt implantation augmented with Mitomycin C in patients with pseudoexfoliation glaucoma (PEXG) and primary open-angle glaucoma (POAG).<h4>Methods</h4>In this retrospective, single centre, interventional study, 46 eyes of 41 patients with PEXG (20 eyes) and POAG (26 eyes) underwent microshunt implantation. Definition of failure was an intraocular pressure (IOP) lower than 5 or higher than 17mmHg on two consecutive visits, an IOP reduction lower than 20% on two consecutive visits, the need of surgical revisions or reoperations or loss of light perception. Outcome was rated as complete success if achieved without medication, otherwise as qualified success. Furthermore, postoperative complications and interventions were compared between the two groups.<h4>Results</h4>Patient demographics were similar, except for older age in the PEXG group (70.9±8.6 versus 77.6±8; p = 0.02). Mean IOP dropped from 21.5±5.8mmHg (PEXG) and 18.2±4.5mmHg (POAG) at baseline to 12.8±3.0mmHg (p<0.0001) and 12.9±4.2mmHg (p<0.0001), respectively, at one year. Mean number of medications were reduced from 2.8±1.3 to 0.3±0.8 for PEXG patients (p<0.0001) and from 2.7±1.3 to 0.3±0.8 for POAG patients (p<0.0001). At one year of follow-up 75.0% of PEXG patients achieved complete success and 80.0% qualified success. In the POAG group rates were 73.1% and 76.9%, respectively. Postoperative complications were comparable between both groups, except for higher rates of hypotony (p = 0.04) and choroidal detachment (p = 0.03) in the PEXG group.<h4>Conclusion</h4>Microshunt implantation demonstrated similar efficacy results in PEXG and POAG eyes at a follow-up of 12 months. Higher rates of transient hypotony and choroidal detachment were observed in PEXG eyes.Matthias NoblSigrid FreissingerStefan KassumehSiegfried PriglingerMarc J MackertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256670 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthias Nobl Sigrid Freissinger Stefan Kassumeh Siegfried Priglinger Marc J Mackert One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
description	<h4>Purpose</h4>To compare the safety and efficacy of microshunt implantation augmented with Mitomycin C in patients with pseudoexfoliation glaucoma (PEXG) and primary open-angle glaucoma (POAG).<h4>Methods</h4>In this retrospective, single centre, interventional study, 46 eyes of 41 patients with PEXG (20 eyes) and POAG (26 eyes) underwent microshunt implantation. Definition of failure was an intraocular pressure (IOP) lower than 5 or higher than 17mmHg on two consecutive visits, an IOP reduction lower than 20% on two consecutive visits, the need of surgical revisions or reoperations or loss of light perception. Outcome was rated as complete success if achieved without medication, otherwise as qualified success. Furthermore, postoperative complications and interventions were compared between the two groups.<h4>Results</h4>Patient demographics were similar, except for older age in the PEXG group (70.9±8.6 versus 77.6±8; p = 0.02). Mean IOP dropped from 21.5±5.8mmHg (PEXG) and 18.2±4.5mmHg (POAG) at baseline to 12.8±3.0mmHg (p<0.0001) and 12.9±4.2mmHg (p<0.0001), respectively, at one year. Mean number of medications were reduced from 2.8±1.3 to 0.3±0.8 for PEXG patients (p<0.0001) and from 2.7±1.3 to 0.3±0.8 for POAG patients (p<0.0001). At one year of follow-up 75.0% of PEXG patients achieved complete success and 80.0% qualified success. In the POAG group rates were 73.1% and 76.9%, respectively. Postoperative complications were comparable between both groups, except for higher rates of hypotony (p = 0.04) and choroidal detachment (p = 0.03) in the PEXG group.<h4>Conclusion</h4>Microshunt implantation demonstrated similar efficacy results in PEXG and POAG eyes at a follow-up of 12 months. Higher rates of transient hypotony and choroidal detachment were observed in PEXG eyes.
format	article
author	Matthias Nobl Sigrid Freissinger Stefan Kassumeh Siegfried Priglinger Marc J Mackert
author_facet	Matthias Nobl Sigrid Freissinger Stefan Kassumeh Siegfried Priglinger Marc J Mackert
author_sort	Matthias Nobl
title	One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
title_short	One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
title_full	One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
title_fullStr	One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
title_full_unstemmed	One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
title_sort	one-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ecca88d6b9fa46fd970704a2d5de84cb
work_keys_str_mv	AT matthiasnobl oneyearoutcomesofmicroshuntimplantationinpseudoexfoliationglaucoma AT sigridfreissinger oneyearoutcomesofmicroshuntimplantationinpseudoexfoliationglaucoma AT stefankassumeh oneyearoutcomesofmicroshuntimplantationinpseudoexfoliationglaucoma AT siegfriedpriglinger oneyearoutcomesofmicroshuntimplantationinpseudoexfoliationglaucoma AT marcjmackert oneyearoutcomesofmicroshuntimplantationinpseudoexfoliationglaucoma
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One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma.

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