Temporal discounting in adolescents and adults with Tourette syndrome.

Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. In this study, we examine whet...

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Autores principales:	Canan Beate Schüller, Ben Jonathan Wagner, Thomas Schüller, Juan Carlos Baldermann, Daniel Huys, Julia Kerner Auch Koerner, Eva Niessen, Alexander Münchau, Valerie Brandt, Jan Peters, Jens Kuhn
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eccb4bd68c6d43c29895e683d5723b40
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spelling	oai:doaj.org-article:eccb4bd68c6d43c29895e683d5723b402021-12-02T20:10:20ZTemporal discounting in adolescents and adults with Tourette syndrome.1932-620310.1371/journal.pone.0253620https://doaj.org/article/eccb4bd68c6d43c29895e683d5723b402021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253620https://doaj.org/toc/1932-6203Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. In this study, we examine whether this extends to changes in temporal discounting, where impulsivity is operationalized as an increased preference for smaller-but-sooner over larger-but-later rewards. We assessed intertemporal choice in two studies including nineteen adolescents (age: mean[sd] = 14.21[±2.37], 13 male subjects) and twenty-five adult patients (age: mean[sd] = 29.88 [±9.03]; 19 male subjects) with Tourette syndrome and healthy age- and education matched controls. Computational modeling using exponential and hyperbolic discounting models via hierarchical Bayesian parameter estimation revealed reduced temporal discounting in adolescent patients, and no evidence for differences in adult patients. Results are discussed with respect to neural models of temporal discounting, dopaminergic alterations in Tourette syndrome and the developmental trajectory of temporal discounting. Specifically, adolescents might show attenuated discounting due to improved inhibitory functions that also affect choice impulsivity and/or the developmental trajectory of executive control functions. Future studies would benefit from a longitudinal approach to further elucidate the developmental trajectory of these effects.Canan Beate SchüllerBen Jonathan WagnerThomas SchüllerJuan Carlos BaldermannDaniel HuysJulia Kerner Auch KoernerEva NiessenAlexander MünchauValerie BrandtJan PetersJens KuhnPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253620 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Canan Beate Schüller Ben Jonathan Wagner Thomas Schüller Juan Carlos Baldermann Daniel Huys Julia Kerner Auch Koerner Eva Niessen Alexander Münchau Valerie Brandt Jan Peters Jens Kuhn Temporal discounting in adolescents and adults with Tourette syndrome.
description	Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. In this study, we examine whether this extends to changes in temporal discounting, where impulsivity is operationalized as an increased preference for smaller-but-sooner over larger-but-later rewards. We assessed intertemporal choice in two studies including nineteen adolescents (age: mean[sd] = 14.21[±2.37], 13 male subjects) and twenty-five adult patients (age: mean[sd] = 29.88 [±9.03]; 19 male subjects) with Tourette syndrome and healthy age- and education matched controls. Computational modeling using exponential and hyperbolic discounting models via hierarchical Bayesian parameter estimation revealed reduced temporal discounting in adolescent patients, and no evidence for differences in adult patients. Results are discussed with respect to neural models of temporal discounting, dopaminergic alterations in Tourette syndrome and the developmental trajectory of temporal discounting. Specifically, adolescents might show attenuated discounting due to improved inhibitory functions that also affect choice impulsivity and/or the developmental trajectory of executive control functions. Future studies would benefit from a longitudinal approach to further elucidate the developmental trajectory of these effects.
format	article
author	Canan Beate Schüller Ben Jonathan Wagner Thomas Schüller Juan Carlos Baldermann Daniel Huys Julia Kerner Auch Koerner Eva Niessen Alexander Münchau Valerie Brandt Jan Peters Jens Kuhn
author_facet	Canan Beate Schüller Ben Jonathan Wagner Thomas Schüller Juan Carlos Baldermann Daniel Huys Julia Kerner Auch Koerner Eva Niessen Alexander Münchau Valerie Brandt Jan Peters Jens Kuhn
author_sort	Canan Beate Schüller
title	Temporal discounting in adolescents and adults with Tourette syndrome.
title_short	Temporal discounting in adolescents and adults with Tourette syndrome.
title_full	Temporal discounting in adolescents and adults with Tourette syndrome.
title_fullStr	Temporal discounting in adolescents and adults with Tourette syndrome.
title_full_unstemmed	Temporal discounting in adolescents and adults with Tourette syndrome.
title_sort	temporal discounting in adolescents and adults with tourette syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/eccb4bd68c6d43c29895e683d5723b40
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Temporal discounting in adolescents and adults with Tourette syndrome.

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