Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

Chiba et al. describe the use of MS2 bacteriophage coat proteins to develop nanocarriers that display the SARS-CoV-2 spike proteins multivalently for vaccine applications. The vaccine elicited high neutralizing antibody titers and protected Syrian hamsters from virus infection after a single immuniz...

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Autores principales:	Shiho Chiba, Steven J. Frey, Peter J. Halfmann, Makoto Kuroda, Tadashi Maemura, Jie E. Yang, Elizabeth R. Wright, Yoshihiro Kawaoka, Ravi S. Kane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eccc0e36630d4307b1d6da12b00abf09
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spelling	oai:doaj.org-article:eccc0e36630d4307b1d6da12b00abf092021-12-02T15:52:54ZMultivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization10.1038/s42003-021-02128-82399-3642https://doaj.org/article/eccc0e36630d4307b1d6da12b00abf092021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02128-8https://doaj.org/toc/2399-3642Chiba et al. describe the use of MS2 bacteriophage coat proteins to develop nanocarriers that display the SARS-CoV-2 spike proteins multivalently for vaccine applications. The vaccine elicited high neutralizing antibody titers and protected Syrian hamsters from virus infection after a single immunization.Shiho ChibaSteven J. FreyPeter J. HalfmannMakoto KurodaTadashi MaemuraJie E. YangElizabeth R. WrightYoshihiro KawaokaRavi S. KaneNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shiho Chiba Steven J. Frey Peter J. Halfmann Makoto Kuroda Tadashi Maemura Jie E. Yang Elizabeth R. Wright Yoshihiro Kawaoka Ravi S. Kane Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
description	Chiba et al. describe the use of MS2 bacteriophage coat proteins to develop nanocarriers that display the SARS-CoV-2 spike proteins multivalently for vaccine applications. The vaccine elicited high neutralizing antibody titers and protected Syrian hamsters from virus infection after a single immunization.
format	article
author	Shiho Chiba Steven J. Frey Peter J. Halfmann Makoto Kuroda Tadashi Maemura Jie E. Yang Elizabeth R. Wright Yoshihiro Kawaoka Ravi S. Kane
author_facet	Shiho Chiba Steven J. Frey Peter J. Halfmann Makoto Kuroda Tadashi Maemura Jie E. Yang Elizabeth R. Wright Yoshihiro Kawaoka Ravi S. Kane
author_sort	Shiho Chiba
title	Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
title_short	Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
title_full	Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
title_fullStr	Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
title_full_unstemmed	Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
title_sort	multivalent nanoparticle-based vaccines protect hamsters against sars-cov-2 after a single immunization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eccc0e36630d4307b1d6da12b00abf09
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Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

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