The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization

Calcium-independent phospholipase A2β (iPLA2β) is involved in many physiological and pathological processes but the underlying mechanisms are largely unknown. Here, the authors present the structure of dimeric iPLA2β, providing insights into the regulation of its activity and cellular localization....

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Autores principales:	Konstantin R. Malley, Olga Koroleva, Ian Miller, Ruslan Sanishvili, Christopher M. Jenkins, Richard W. Gross, Sergey Korolev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eccf36650d4148448f5ea5a4adc113d8
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spelling	oai:doaj.org-article:eccf36650d4148448f5ea5a4adc113d82021-12-02T15:33:38ZThe structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization10.1038/s41467-018-03193-02041-1723https://doaj.org/article/eccf36650d4148448f5ea5a4adc113d82018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03193-0https://doaj.org/toc/2041-1723Calcium-independent phospholipase A2β (iPLA2β) is involved in many physiological and pathological processes but the underlying mechanisms are largely unknown. Here, the authors present the structure of dimeric iPLA2β, providing insights into the regulation of its activity and cellular localization.Konstantin R. MalleyOlga KorolevaIan MillerRuslan SanishviliChristopher M. JenkinsRichard W. GrossSergey KorolevNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstantin R. Malley Olga Koroleva Ian Miller Ruslan Sanishvili Christopher M. Jenkins Richard W. Gross Sergey Korolev The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
description	Calcium-independent phospholipase A2β (iPLA2β) is involved in many physiological and pathological processes but the underlying mechanisms are largely unknown. Here, the authors present the structure of dimeric iPLA2β, providing insights into the regulation of its activity and cellular localization.
format	article
author	Konstantin R. Malley Olga Koroleva Ian Miller Ruslan Sanishvili Christopher M. Jenkins Richard W. Gross Sergey Korolev
author_facet	Konstantin R. Malley Olga Koroleva Ian Miller Ruslan Sanishvili Christopher M. Jenkins Richard W. Gross Sergey Korolev
author_sort	Konstantin R. Malley
title	The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
title_short	The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
title_full	The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
title_fullStr	The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
title_full_unstemmed	The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
title_sort	structure of ipla2β reveals dimeric active sites and suggests mechanisms of regulation and localization
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eccf36650d4148448f5ea5a4adc113d8
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The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization

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