Polymorphic Regulation of Outer Membrane Lipid A Composition
ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now...
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| Format: | article |
| Language: | EN |
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American Society for Microbiology
2016
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| Online Access: | https://doaj.org/article/ecd22f900f9b437a9393ba0221e6f7d1 |
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| Summary: | ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now. In a recent article in mBio [7(5):e01532-16, https://doi.org/10.1128/mBio.01532-16], Katherine E. Bonnington and Meta J. Kuehn of Duke University’s Department of Biochemistry make a compelling case for considering how the molecular shapes of the various lipid A structural subtypes found in the outer membrane contribute to the process of outer membrane vesicle (OMV) formation. |
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