Polymorphic Regulation of Outer Membrane Lipid A Composition
ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now...
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American Society for Microbiology
2016
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oai:doaj.org-article:ecd22f900f9b437a9393ba0221e6f7d12021-11-15T15:50:17ZPolymorphic Regulation of Outer Membrane Lipid A Composition10.1128/mBio.01903-162150-7511https://doaj.org/article/ecd22f900f9b437a9393ba0221e6f7d12016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01903-16https://doaj.org/toc/2150-7511ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now. In a recent article in mBio [7(5):e01532-16, https://doi.org/10.1128/mBio.01532-16], Katherine E. Bonnington and Meta J. Kuehn of Duke University’s Department of Biochemistry make a compelling case for considering how the molecular shapes of the various lipid A structural subtypes found in the outer membrane contribute to the process of outer membrane vesicle (OMV) formation.Russell E. BishopAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016) |
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DOAJ |
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EN |
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Microbiology QR1-502 |
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Microbiology QR1-502 Russell E. Bishop Polymorphic Regulation of Outer Membrane Lipid A Composition |
| description |
ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now. In a recent article in mBio [7(5):e01532-16, https://doi.org/10.1128/mBio.01532-16], Katherine E. Bonnington and Meta J. Kuehn of Duke University’s Department of Biochemistry make a compelling case for considering how the molecular shapes of the various lipid A structural subtypes found in the outer membrane contribute to the process of outer membrane vesicle (OMV) formation. |
| format |
article |
| author |
Russell E. Bishop |
| author_facet |
Russell E. Bishop |
| author_sort |
Russell E. Bishop |
| title |
Polymorphic Regulation of Outer Membrane Lipid A Composition |
| title_short |
Polymorphic Regulation of Outer Membrane Lipid A Composition |
| title_full |
Polymorphic Regulation of Outer Membrane Lipid A Composition |
| title_fullStr |
Polymorphic Regulation of Outer Membrane Lipid A Composition |
| title_full_unstemmed |
Polymorphic Regulation of Outer Membrane Lipid A Composition |
| title_sort |
polymorphic regulation of outer membrane lipid a composition |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
https://doaj.org/article/ecd22f900f9b437a9393ba0221e6f7d1 |
| work_keys_str_mv |
AT russellebishop polymorphicregulationofoutermembranelipidacomposition |
| _version_ |
1718427434594861056 |