Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

Hazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology,...

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Autores principales:	Saleh HM, Soliman OA, Elshazly MO, Raafat A, Gohar AK, Salaheldin TA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	In-vivo Changes Nanogold Hamsters Histopathology Hematology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ecd2cea195a04d06a817b7c9fab9f33a
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spelling	oai:doaj.org-article:ecd2cea195a04d06a817b7c9fab9f33a2021-12-02T05:14:21ZAcute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters1178-2013https://doaj.org/article/ecd2cea195a04d06a817b7c9fab9f33a2016-06-01T00:00:00Zhttps://www.dovepress.com/acute-hematologic-hepatologic-and-nephrologic-changes-after-intraperit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 4Nanotechnology & Advanced Materials Central Laboratory, Agricultural Research Center, Guiza, EgyptAbstract: In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.Keywords: in vivo, hamsters, nanogold, acuteSaleh HMSoliman OAElshazly MORaafat AGohar AKSalaheldin TADove Medical PressarticleIn-vivoChangesNanogoldHamstersHistopathologyHematologyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2505-2513 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	In-vivo Changes Nanogold Hamsters Histopathology Hematology Medicine (General) R5-920
spellingShingle	In-vivo Changes Nanogold Hamsters Histopathology Hematology Medicine (General) R5-920 Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
description	Hazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 4Nanotechnology & Advanced Materials Central Laboratory, Agricultural Research Center, Guiza, EgyptAbstract: In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.Keywords: in vivo, hamsters, nanogold, acute
format	article
author	Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA
author_facet	Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA
author_sort	Saleh HM
title	Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
title_short	Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
title_full	Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
title_fullStr	Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
title_full_unstemmed	Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
title_sort	acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/ecd2cea195a04d06a817b7c9fab9f33a
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Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

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