Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity towards CYP redox partners, activating distinct metab...

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Autores principales:	Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E. Moses, Cecilie C. Hansen, Johannes Thomsen, Magnus B. Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M. Lund, Patricia R. Castaño, Yanet G. Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V. Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S. Hatzakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecd3eccafadb4f149283420e2e8e2cea
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spelling	oai:doaj.org-article:ecd3eccafadb4f149283420e2e8e2cea2021-12-02T18:03:25ZBiased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase10.1038/s41467-021-22562-w2041-1723https://doaj.org/article/ecd3eccafadb4f149283420e2e8e2cea2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22562-whttps://doaj.org/toc/2041-1723P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity towards CYP redox partners, activating distinct metabolic cascades in cells.Simon Bo JensenSara ThodbergShaheena ParweenMatias E. MosesCecilie C. HansenJohannes ThomsenMagnus B. SletfjerdingCamilla KnudsenRita Del GiudicePhilip M. LundPatricia R. CastañoYanet G. BustamanteMaria Natalia Rojas VelazquezFlemming Steen JørgensenAmit V. PandeyTomas LaursenBirger Lindberg MøllerNikos S. HatzakisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Bo Jensen Sara Thodberg Shaheena Parween Matias E. Moses Cecilie C. Hansen Johannes Thomsen Magnus B. Sletfjerding Camilla Knudsen Rita Del Giudice Philip M. Lund Patricia R. Castaño Yanet G. Bustamante Maria Natalia Rojas Velazquez Flemming Steen Jørgensen Amit V. Pandey Tomas Laursen Birger Lindberg Møller Nikos S. Hatzakis Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
description	P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity towards CYP redox partners, activating distinct metabolic cascades in cells.
format	article
author	Simon Bo Jensen Sara Thodberg Shaheena Parween Matias E. Moses Cecilie C. Hansen Johannes Thomsen Magnus B. Sletfjerding Camilla Knudsen Rita Del Giudice Philip M. Lund Patricia R. Castaño Yanet G. Bustamante Maria Natalia Rojas Velazquez Flemming Steen Jørgensen Amit V. Pandey Tomas Laursen Birger Lindberg Møller Nikos S. Hatzakis
author_facet	Simon Bo Jensen Sara Thodberg Shaheena Parween Matias E. Moses Cecilie C. Hansen Johannes Thomsen Magnus B. Sletfjerding Camilla Knudsen Rita Del Giudice Philip M. Lund Patricia R. Castaño Yanet G. Bustamante Maria Natalia Rojas Velazquez Flemming Steen Jørgensen Amit V. Pandey Tomas Laursen Birger Lindberg Møller Nikos S. Hatzakis
author_sort	Simon Bo Jensen
title	Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
title_short	Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
title_full	Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
title_fullStr	Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
title_full_unstemmed	Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
title_sort	biased cytochrome p450-mediated metabolism via small-molecule ligands binding p450 oxidoreductase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ecd3eccafadb4f149283420e2e8e2cea
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Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

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