Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study

Objective:Turner syndrome (TS) patients are at high risk of cardiometabolic disorders. Cardiometabolic risk factors are more commonly related to visceral rather than total body adiposity. Adipocytokines have been explored as a potential link between obesity and obesity-related cardiometabolic dysfun...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nanees A. Salem, Nihal M. Batouty, Ahmed M. Tawfik, Donia M. Sobh, Basma Gadelhak, Shimaa R. Hendawy, Wafaa Laimon
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayincilik 2021
Materias:	epicardial fat perihepatic fat metabolic syndrome turner syndrome Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/ecddd34c152d4ad5b5e2e216545236bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ecddd34c152d4ad5b5e2e216545236bd
record_format	dspace
spelling	oai:doaj.org-article:ecddd34c152d4ad5b5e2e216545236bd2021-11-26T06:10:16ZEpicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study1308-57271308-573510.4274/jcrpe.galenos.2021.2021.0030https://doaj.org/article/ecddd34c152d4ad5b5e2e216545236bd2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/epicardial-and-perihepatic-fat-as-cardiometabolic-/47426 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:Turner syndrome (TS) patients are at high risk of cardiometabolic disorders. Cardiometabolic risk factors are more commonly related to visceral rather than total body adiposity. Adipocytokines have been explored as a potential link between obesity and obesity-related cardiometabolic dysfunction. This study explored the validity of epicardial fat-thickness (EFT) and perihepatic fat-thickness (PHFT) measurement as cardiometabolic-risk predictors in TS-girls in relation to standard obesity-indices and metabolic syndrome (MetS) components.Methods:Forty-six TS girls and twenty-five controls (10-16 years) were subdivided into two age-groups (10 to less than 13 and 13-16). Participants were assessed for body mass index (BMI) Z-scores, waist circumference (WC), total-fat mass (FM) and trunk-FM by bioimpedance-technique, EFT and PHFT by cardiovascular magnetic resonance, lipid-profile, homeostasis model assessment of insulin resistance (HOMA-IR), and serum chemerin. MetS was defined according to International Diabetes Federation criteria.Results:Overweight/obesity and MetS were detected in 45.7% and 37% of TS-girls respectively. BMI Z-score, WC, total-FM, trunk-FM, EFT and PHFT values were significantly higher in TS-age groups compared to age-matched control groups, being more pronounced in the older group when TS-girls had been exposed to estrogen. Dyslipidemia, higher HOMA-IR, chemerin, EFT and PHFT values were observed in lean-Turner compared to BMI-Z-matched controls. EFT and PHFT were significantly correlated with chemerin and several components of MetS. EFT at a cut-off-value of 6.20 mm (area under the curve=0.814) can predict MetS in TS-girls.Conclusion:TS-girls displayed an adverse cardiometabolic profile during late childhood and adolescence. EFT and PHFT are emerging cardiometabolic risk predictors in TS-patients. Excess EFT rather than total body adiposity may contribute to altered metabolic profile among lean-Turner patients.Nanees A. SalemNihal M. BatoutyAhmed M. TawfikDonia M. SobhBasma GadelhakShimaa R. HendawyWafaa LaimonGalenos Yayincilikarticleepicardial fatperihepatic fatmetabolic syndrometurner syndromePediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 408-417 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epicardial fat perihepatic fat metabolic syndrome turner syndrome Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	epicardial fat perihepatic fat metabolic syndrome turner syndrome Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Nanees A. Salem Nihal M. Batouty Ahmed M. Tawfik Donia M. Sobh Basma Gadelhak Shimaa R. Hendawy Wafaa Laimon Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
description	Objective:Turner syndrome (TS) patients are at high risk of cardiometabolic disorders. Cardiometabolic risk factors are more commonly related to visceral rather than total body adiposity. Adipocytokines have been explored as a potential link between obesity and obesity-related cardiometabolic dysfunction. This study explored the validity of epicardial fat-thickness (EFT) and perihepatic fat-thickness (PHFT) measurement as cardiometabolic-risk predictors in TS-girls in relation to standard obesity-indices and metabolic syndrome (MetS) components.Methods:Forty-six TS girls and twenty-five controls (10-16 years) were subdivided into two age-groups (10 to less than 13 and 13-16). Participants were assessed for body mass index (BMI) Z-scores, waist circumference (WC), total-fat mass (FM) and trunk-FM by bioimpedance-technique, EFT and PHFT by cardiovascular magnetic resonance, lipid-profile, homeostasis model assessment of insulin resistance (HOMA-IR), and serum chemerin. MetS was defined according to International Diabetes Federation criteria.Results:Overweight/obesity and MetS were detected in 45.7% and 37% of TS-girls respectively. BMI Z-score, WC, total-FM, trunk-FM, EFT and PHFT values were significantly higher in TS-age groups compared to age-matched control groups, being more pronounced in the older group when TS-girls had been exposed to estrogen. Dyslipidemia, higher HOMA-IR, chemerin, EFT and PHFT values were observed in lean-Turner compared to BMI-Z-matched controls. EFT and PHFT were significantly correlated with chemerin and several components of MetS. EFT at a cut-off-value of 6.20 mm (area under the curve=0.814) can predict MetS in TS-girls.Conclusion:TS-girls displayed an adverse cardiometabolic profile during late childhood and adolescence. EFT and PHFT are emerging cardiometabolic risk predictors in TS-patients. Excess EFT rather than total body adiposity may contribute to altered metabolic profile among lean-Turner patients.
format	article
author	Nanees A. Salem Nihal M. Batouty Ahmed M. Tawfik Donia M. Sobh Basma Gadelhak Shimaa R. Hendawy Wafaa Laimon
author_facet	Nanees A. Salem Nihal M. Batouty Ahmed M. Tawfik Donia M. Sobh Basma Gadelhak Shimaa R. Hendawy Wafaa Laimon
author_sort	Nanees A. Salem
title	Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
title_short	Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
title_full	Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
title_fullStr	Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
title_full_unstemmed	Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
title_sort	epicardial and perihepatic fat as cardiometabolic risk predictors in girls with turner syndrome: a cardiac magnetic resonance study
publisher	Galenos Yayincilik
publishDate	2021
url	https://doaj.org/article/ecddd34c152d4ad5b5e2e216545236bd
work_keys_str_mv	AT naneesasalem epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT nihalmbatouty epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT ahmedmtawfik epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT doniamsobh epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT basmagadelhak epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT shimaarhendawy epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy AT wafaalaimon epicardialandperihepaticfatascardiometabolicriskpredictorsingirlswithturnersyndromeacardiacmagneticresonancestudy
_version_	1718409816139890688

Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study

Ejemplares similares