Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

G Deepa,1 Arun Kumar T Thulasidasan,2 Ruby John Anto,2 J Jisha Pillai,1 GS Vinod Kumar11Chemical Biology, 2Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, IndiaObjective: To investigate cross-linked hydrogels prepared via inverse emulsion polymerizatio...

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Autores principales:	Pillai JJ, Kumar GS, Anto RJ, Deepa G, Thulasidasan AK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ecdef002b3bd4afd88d055d19cdc2ed3
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spelling	oai:doaj.org-article:ecdef002b3bd4afd88d055d19cdc2ed32021-12-02T05:02:10ZCross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy1176-91141178-2013https://doaj.org/article/ecdef002b3bd4afd88d055d19cdc2ed32012-07-01T00:00:00Zhttp://www.dovepress.com/cross-linked-acrylic-hydrogel-for-the-controlled-delivery-of-hydrophob-a10537https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013G Deepa,1 Arun Kumar T Thulasidasan,2 Ruby John Anto,2 J Jisha Pillai,1 GS Vinod Kumar11Chemical Biology, 2Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, IndiaObjective: To investigate cross-linked hydrogels prepared via inverse emulsion polymerization to entrap poorly aqueous soluble drugs. Polyethylene glycol cross-linked acrylic polymers were synthesized and the loading and release of curcumin, a model hydrophobic drug, was investigated.Methods: Physicochemical characteristics of hydrogels were studied with 13C nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, differential scanning calorimetry, and swelling. Polymerization of the acrylic acid with cross-linked polyethylene glycol diacrylate was characterized with 13C nuclear magnetic resonance imaging and Fourier transform infrared spectroscopy.Results: The in vitro release rate of curcumin showed that there was a sustained release from the hydrogel with increased cross-linking; the release rate depended on the pH of the releasing medium. Intracellular and cytotoxicity studies were carried out in human cervical cancer cell lines.Conclusion: The results suggest cross-linked acrylic polymers can be used as efficient vectors for pH-sensitive, controlled delivery of hydrophobic drugs.Keywords: curcumin, cross-linked polyethylene glycol, polyacrylic acid, nanogel, cross-linking combinations, HeLaPillai JJKumar GSAnto RJDeepa GThulasidasan AKDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4077-4088 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Pillai JJ Kumar GS Anto RJ Deepa G Thulasidasan AK Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
description	G Deepa,1 Arun Kumar T Thulasidasan,2 Ruby John Anto,2 J Jisha Pillai,1 GS Vinod Kumar11Chemical Biology, 2Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, IndiaObjective: To investigate cross-linked hydrogels prepared via inverse emulsion polymerization to entrap poorly aqueous soluble drugs. Polyethylene glycol cross-linked acrylic polymers were synthesized and the loading and release of curcumin, a model hydrophobic drug, was investigated.Methods: Physicochemical characteristics of hydrogels were studied with 13C nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, differential scanning calorimetry, and swelling. Polymerization of the acrylic acid with cross-linked polyethylene glycol diacrylate was characterized with 13C nuclear magnetic resonance imaging and Fourier transform infrared spectroscopy.Results: The in vitro release rate of curcumin showed that there was a sustained release from the hydrogel with increased cross-linking; the release rate depended on the pH of the releasing medium. Intracellular and cytotoxicity studies were carried out in human cervical cancer cell lines.Conclusion: The results suggest cross-linked acrylic polymers can be used as efficient vectors for pH-sensitive, controlled delivery of hydrophobic drugs.Keywords: curcumin, cross-linked polyethylene glycol, polyacrylic acid, nanogel, cross-linking combinations, HeLa
format	article
author	Pillai JJ Kumar GS Anto RJ Deepa G Thulasidasan AK
author_facet	Pillai JJ Kumar GS Anto RJ Deepa G Thulasidasan AK
author_sort	Pillai JJ
title	Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
title_short	Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
title_full	Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
title_fullStr	Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
title_full_unstemmed	Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
title_sort	cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/ecdef002b3bd4afd88d055d19cdc2ed3
work_keys_str_mv	AT pillaijj crosslinkedacrylichydrogelforthecontrolleddeliveryofhydrophobicdrugsincancertherapy AT kumargs crosslinkedacrylichydrogelforthecontrolleddeliveryofhydrophobicdrugsincancertherapy AT antorj crosslinkedacrylichydrogelforthecontrolleddeliveryofhydrophobicdrugsincancertherapy AT deepag crosslinkedacrylichydrogelforthecontrolleddeliveryofhydrophobicdrugsincancertherapy AT thulasidasanak crosslinkedacrylichydrogelforthecontrolleddeliveryofhydrophobicdrugsincancertherapy
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Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

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