Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.

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Autores principales:	Zachary S. Lorsch, Yong-Hwee Eddie Loh, Immanuel Purushothaman, Deena M. Walker, Eric M. Parise, Marine Salery, Michael E. Cahill, Georgia E. Hodes, Madeline L. Pfau, Hope Kronman, Peter J. Hamilton, Orna Issler, Benoit Labonté, Ann E. Symonds, Matthew Zucker, Tie Yuan Zhang, Michael J. Meaney, Scott J. Russo, Li Shen, Rosemary C. Bagot, Eric J. Nestler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ece077944a9741a483557c3a2aad83ec
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spelling	oai:doaj.org-article:ece077944a9741a483557c3a2aad83ec2021-12-02T14:40:44ZEstrogen receptor α drives pro-resilient transcription in mouse models of depression10.1038/s41467-018-03567-42041-1723https://doaj.org/article/ece077944a9741a483557c3a2aad83ec2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03567-4https://doaj.org/toc/2041-1723Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.Zachary S. LorschYong-Hwee Eddie LohImmanuel PurushothamanDeena M. WalkerEric M. PariseMarine SaleryMichael E. CahillGeorgia E. HodesMadeline L. PfauHope KronmanPeter J. HamiltonOrna IsslerBenoit LabontéAnn E. SymondsMatthew ZuckerTie Yuan ZhangMichael J. MeaneyScott J. RussoLi ShenRosemary C. BagotEric J. NestlerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zachary S. Lorsch Yong-Hwee Eddie Loh Immanuel Purushothaman Deena M. Walker Eric M. Parise Marine Salery Michael E. Cahill Georgia E. Hodes Madeline L. Pfau Hope Kronman Peter J. Hamilton Orna Issler Benoit Labonté Ann E. Symonds Matthew Zucker Tie Yuan Zhang Michael J. Meaney Scott J. Russo Li Shen Rosemary C. Bagot Eric J. Nestler Estrogen receptor α drives pro-resilient transcription in mouse models of depression
description	Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.
format	article
author	Zachary S. Lorsch Yong-Hwee Eddie Loh Immanuel Purushothaman Deena M. Walker Eric M. Parise Marine Salery Michael E. Cahill Georgia E. Hodes Madeline L. Pfau Hope Kronman Peter J. Hamilton Orna Issler Benoit Labonté Ann E. Symonds Matthew Zucker Tie Yuan Zhang Michael J. Meaney Scott J. Russo Li Shen Rosemary C. Bagot Eric J. Nestler
author_facet	Zachary S. Lorsch Yong-Hwee Eddie Loh Immanuel Purushothaman Deena M. Walker Eric M. Parise Marine Salery Michael E. Cahill Georgia E. Hodes Madeline L. Pfau Hope Kronman Peter J. Hamilton Orna Issler Benoit Labonté Ann E. Symonds Matthew Zucker Tie Yuan Zhang Michael J. Meaney Scott J. Russo Li Shen Rosemary C. Bagot Eric J. Nestler
author_sort	Zachary S. Lorsch
title	Estrogen receptor α drives pro-resilient transcription in mouse models of depression
title_short	Estrogen receptor α drives pro-resilient transcription in mouse models of depression
title_full	Estrogen receptor α drives pro-resilient transcription in mouse models of depression
title_fullStr	Estrogen receptor α drives pro-resilient transcription in mouse models of depression
title_full_unstemmed	Estrogen receptor α drives pro-resilient transcription in mouse models of depression
title_sort	estrogen receptor α drives pro-resilient transcription in mouse models of depression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ece077944a9741a483557c3a2aad83ec
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Estrogen receptor α drives pro-resilient transcription in mouse models of depression

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