Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations
Abstract Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT structure caused by PAPS binding could control...
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| Auteurs principaux: | , , , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/ece2219aba824e04a7c747cf0ec901a5 |
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