Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells

Extracellular vesicles mediate cell–cell communication, however, their capacity to deliver their content within acceptor cells is unclear. Here, the authors develop a quantitative assay and show that release of extracellular vesicle contents requires endosomal acidification and may involve membrane...

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Autores principales:	Emeline Bonsergent, Eleonora Grisard, Julian Buchrieser, Olivier Schwartz, Clotilde Théry, Grégory Lavieu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ece2db4046514778818273a46db0be84
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spelling	oai:doaj.org-article:ece2db4046514778818273a46db0be842021-12-02T16:36:00ZQuantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells10.1038/s41467-021-22126-y2041-1723https://doaj.org/article/ece2db4046514778818273a46db0be842021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22126-yhttps://doaj.org/toc/2041-1723Extracellular vesicles mediate cell–cell communication, however, their capacity to deliver their content within acceptor cells is unclear. Here, the authors develop a quantitative assay and show that release of extracellular vesicle contents requires endosomal acidification and may involve membrane fusion.Emeline BonsergentEleonora GrisardJulian BuchrieserOlivier SchwartzClotilde ThéryGrégory LavieuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emeline Bonsergent Eleonora Grisard Julian Buchrieser Olivier Schwartz Clotilde Théry Grégory Lavieu Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
description	Extracellular vesicles mediate cell–cell communication, however, their capacity to deliver their content within acceptor cells is unclear. Here, the authors develop a quantitative assay and show that release of extracellular vesicle contents requires endosomal acidification and may involve membrane fusion.
format	article
author	Emeline Bonsergent Eleonora Grisard Julian Buchrieser Olivier Schwartz Clotilde Théry Grégory Lavieu
author_facet	Emeline Bonsergent Eleonora Grisard Julian Buchrieser Olivier Schwartz Clotilde Théry Grégory Lavieu
author_sort	Emeline Bonsergent
title	Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
title_short	Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
title_full	Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
title_fullStr	Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
title_full_unstemmed	Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
title_sort	quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ece2db4046514778818273a46db0be84
work_keys_str_mv	AT emelinebonsergent quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells AT eleonoragrisard quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells AT julianbuchrieser quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells AT olivierschwartz quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells AT clotildethery quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells AT gregorylavieu quantitativecharacterizationofextracellularvesicleuptakeandcontentdeliverywithinmammaliancells
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Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells

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