Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial
Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast cancer, the authors demonstrate that FMD is safe an...
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Nature Portfolio
2020
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oai:doaj.org-article:ece7e746301b495eb80ac3a8146970992021-12-02T16:06:04ZFasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial10.1038/s41467-020-16138-32041-1723https://doaj.org/article/ece7e746301b495eb80ac3a8146970992020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16138-3https://doaj.org/toc/2041-1723Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast cancer, the authors demonstrate that FMD is safe and enhances the effects of neoadjuvant chemotherapy on radiological and pathological tumor response.Stefanie de GrootRieneke T. LugtenbergDanielle CohenMarij J. P. WeltersIlina EhsanMaaike P. G. VreeswijkVincent T. H. B. M. SmitHiltje de GraafJoan B. HeijnsJohanneke E. A. PortieljeAgnes J. van de WouwAlex L. T. ImholzLonneke W. KesselsSuzan VrijaldenhovenArnold BaarsElma Meershoek-Klein KranenbargMarjolijn Duijm-de CarpentierHein PutterJacobus J. M. van der HoevenJohan W. R. NortierValter D. LongoHanno PijlJudith R. KroepDutch Breast Cancer Research Group (BOOG)Nature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q Stefanie de Groot Rieneke T. Lugtenberg Danielle Cohen Marij J. P. Welters Ilina Ehsan Maaike P. G. Vreeswijk Vincent T. H. B. M. Smit Hiltje de Graaf Joan B. Heijns Johanneke E. A. Portielje Agnes J. van de Wouw Alex L. T. Imholz Lonneke W. Kessels Suzan Vrijaldenhoven Arnold Baars Elma Meershoek-Klein Kranenbarg Marjolijn Duijm-de Carpentier Hein Putter Jacobus J. M. van der Hoeven Johan W. R. Nortier Valter D. Longo Hanno Pijl Judith R. Kroep Dutch Breast Cancer Research Group (BOOG) Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| description |
Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast cancer, the authors demonstrate that FMD is safe and enhances the effects of neoadjuvant chemotherapy on radiological and pathological tumor response. |
| format |
article |
| author |
Stefanie de Groot Rieneke T. Lugtenberg Danielle Cohen Marij J. P. Welters Ilina Ehsan Maaike P. G. Vreeswijk Vincent T. H. B. M. Smit Hiltje de Graaf Joan B. Heijns Johanneke E. A. Portielje Agnes J. van de Wouw Alex L. T. Imholz Lonneke W. Kessels Suzan Vrijaldenhoven Arnold Baars Elma Meershoek-Klein Kranenbarg Marjolijn Duijm-de Carpentier Hein Putter Jacobus J. M. van der Hoeven Johan W. R. Nortier Valter D. Longo Hanno Pijl Judith R. Kroep Dutch Breast Cancer Research Group (BOOG) |
| author_facet |
Stefanie de Groot Rieneke T. Lugtenberg Danielle Cohen Marij J. P. Welters Ilina Ehsan Maaike P. G. Vreeswijk Vincent T. H. B. M. Smit Hiltje de Graaf Joan B. Heijns Johanneke E. A. Portielje Agnes J. van de Wouw Alex L. T. Imholz Lonneke W. Kessels Suzan Vrijaldenhoven Arnold Baars Elma Meershoek-Klein Kranenbarg Marjolijn Duijm-de Carpentier Hein Putter Jacobus J. M. van der Hoeven Johan W. R. Nortier Valter D. Longo Hanno Pijl Judith R. Kroep Dutch Breast Cancer Research Group (BOOG) |
| author_sort |
Stefanie de Groot |
| title |
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| title_short |
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| title_full |
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| title_fullStr |
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| title_full_unstemmed |
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial |
| title_sort |
fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 direct trial |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ece7e746301b495eb80ac3a814697099 |
| work_keys_str_mv |
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