Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Yibeltal Yismaw Gela,1 Ayechew Adera Getu,1 Aynishet Adane,2 Bezawit Mulat Ayal,1 Yonas Akalu,1 Adugnaw Ambelu,1 Mengistie Diress,1 Yigizie Yeshaw1,3 1Department of Physiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, College...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gela YY, Getu AA, Adane A, Ayal BM, Akalu Y, Ambelu A, Diress M, Yeshaw Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cognitive impairment chronic kidney disease smmse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/eced8a27e8cd4e06bff7e9b48803e045
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eced8a27e8cd4e06bff7e9b48803e045
record_format	dspace
spelling	oai:doaj.org-article:eced8a27e8cd4e06bff7e9b48803e0452021-12-02T14:36:42ZCognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study1178-2021https://doaj.org/article/eced8a27e8cd4e06bff7e9b48803e0452021-05-01T00:00:00Zhttps://www.dovepress.com/cognitive-impairment-and-associated-factors-among-chronic-kidney-disea-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Yibeltal Yismaw Gela,1 Ayechew Adera Getu,1 Aynishet Adane,2 Bezawit Mulat Ayal,1 Yonas Akalu,1 Adugnaw Ambelu,1 Mengistie Diress,1 Yigizie Yeshaw1,3 1Department of Physiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Yibeltal Yismaw Gela Email yibeltalyismaw7@gmail.comBackground: Cognitive impairment is one of the public health problems affecting 50 million people in the world. Chronic kidney disease (CKD) patients are at high risk to develop cognitive impairment which leads to poor quality of life, difficulty in adhering to medications, increased risk of mortality, and health resource utilization. However, there is no study done on the prevalence of cognitive impairment and associated factors among chronic kidney disease patients in Ethiopia.Objective: This study aimed to assess the prevalence of cognitive impairment and associated factors among chronic kidney disease patients at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020, Northwest Ethiopia, 2020.Methods: An institution-based comparative cross-sectional study was conducted at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020. A systematic random sampling technique was used to select the study participants. Data were collected using standard tools. Data were checked for its completeness and entered into Epi data version 3.0 then exported into STATA 14. Multi-variable logistic regression analysis was employed to identify associated factors of cognitive impairment among CKD patients, and variables having a p-value of ≤ 0.05 were declared as significant.Results: In this study, 116 CKD patients and 116 age, sex, and educational level matched controls were included with a response rate of 100%. The prevalence of cognitive impairment was 49.1% [95% CI (40%, 58.3%)] among CKD patients and 28.4% [95% CI (20.9%, 37.5%)] among controls. Independent predictors of cognitive impairment among CKD patients were estimated glomerular filtration (eGFR) < 60mL/min/m2 [AOR=3.9, 95% CI (1.1– 14.74)], proteinuria [AOR=6.0, 95% CI (1.83– 20.3)], age greater than 65 years [AOR=4.0, 95% CI (1.12– 14.64)], and educational level of grade 8 and less [AOR= 4.7, 95% CI (1.22 -18.47)].Conclusion: The prevalence of cognitive impairment among CKD patients was higher than healthy controls. Cognitive impairment was higher among CKD patients with eGFR < 60mL/min/m2, proteinuria, educational level of grade 8 and less, and age greater than 65 years. Therefore, there is a need to have a regular evaluation and follow-up of CKD patients for cognitive impairment.Keywords: cognitive impairment, chronic kidney disease, SMMSEGela YYGetu AAAdane AAyal BMAkalu YAmbelu ADiress MYeshaw YDove Medical Pressarticlecognitive impairmentchronic kidney diseasesmmseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1483-1492 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive impairment chronic kidney disease smmse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cognitive impairment chronic kidney disease smmse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gela YY Getu AA Adane A Ayal BM Akalu Y Ambelu A Diress M Yeshaw Y Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
description	Yibeltal Yismaw Gela,1 Ayechew Adera Getu,1 Aynishet Adane,2 Bezawit Mulat Ayal,1 Yonas Akalu,1 Adugnaw Ambelu,1 Mengistie Diress,1 Yigizie Yeshaw1,3 1Department of Physiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Yibeltal Yismaw Gela Email yibeltalyismaw7@gmail.comBackground: Cognitive impairment is one of the public health problems affecting 50 million people in the world. Chronic kidney disease (CKD) patients are at high risk to develop cognitive impairment which leads to poor quality of life, difficulty in adhering to medications, increased risk of mortality, and health resource utilization. However, there is no study done on the prevalence of cognitive impairment and associated factors among chronic kidney disease patients in Ethiopia.Objective: This study aimed to assess the prevalence of cognitive impairment and associated factors among chronic kidney disease patients at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020, Northwest Ethiopia, 2020.Methods: An institution-based comparative cross-sectional study was conducted at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020. A systematic random sampling technique was used to select the study participants. Data were collected using standard tools. Data were checked for its completeness and entered into Epi data version 3.0 then exported into STATA 14. Multi-variable logistic regression analysis was employed to identify associated factors of cognitive impairment among CKD patients, and variables having a p-value of ≤ 0.05 were declared as significant.Results: In this study, 116 CKD patients and 116 age, sex, and educational level matched controls were included with a response rate of 100%. The prevalence of cognitive impairment was 49.1% [95% CI (40%, 58.3%)] among CKD patients and 28.4% [95% CI (20.9%, 37.5%)] among controls. Independent predictors of cognitive impairment among CKD patients were estimated glomerular filtration (eGFR) < 60mL/min/m2 [AOR=3.9, 95% CI (1.1– 14.74)], proteinuria [AOR=6.0, 95% CI (1.83– 20.3)], age greater than 65 years [AOR=4.0, 95% CI (1.12– 14.64)], and educational level of grade 8 and less [AOR= 4.7, 95% CI (1.22 -18.47)].Conclusion: The prevalence of cognitive impairment among CKD patients was higher than healthy controls. Cognitive impairment was higher among CKD patients with eGFR < 60mL/min/m2, proteinuria, educational level of grade 8 and less, and age greater than 65 years. Therefore, there is a need to have a regular evaluation and follow-up of CKD patients for cognitive impairment.Keywords: cognitive impairment, chronic kidney disease, SMMSE
format	article
author	Gela YY Getu AA Adane A Ayal BM Akalu Y Ambelu A Diress M Yeshaw Y
author_facet	Gela YY Getu AA Adane A Ayal BM Akalu Y Ambelu A Diress M Yeshaw Y
author_sort	Gela YY
title	Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
title_short	Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
title_full	Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
title_fullStr	Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
title_full_unstemmed	Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study
title_sort	cognitive impairment and associated factors among chronic kidney disease patients: a comparative cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/eced8a27e8cd4e06bff7e9b48803e045
work_keys_str_mv	AT gelayy cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT getuaa cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT adanea cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT ayalbm cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT akaluy cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT ambelua cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT diressm cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy AT yeshawy cognitiveimpairmentandassociatedfactorsamongchronickidneydiseasepatientsacomparativecrosssectionalstudy
_version_	1718391043599106048

Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Ejemplares similares