Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection.
Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stres...
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2012
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oai:doaj.org-article:ecf40e72827348b2970e39165d5ebfd22021-11-18T07:06:53ZOxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection.1932-620310.1371/journal.pone.0044004https://doaj.org/article/ecf40e72827348b2970e39165d5ebfd22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952850/?tool=EBIhttps://doaj.org/toc/1932-6203Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stress products, a characteristic of Plasmodium infection, as well as proinflammatory response induced by the parasite are involved in its pathophysiology. Therefore, we aimed to investigate the development of malaria-associated AKI during infection by P. berghei ANKA, with special attention to the role played by the inflammatory response and the involvement of oxidative stress. For that, we took advantage of an experimental model of severe malaria that showed significant changes in the renal pathophysiology to investigate the role of malaria infection in the renal microvascular permeability and tissue injury. Therefore, BALB/c mice were infected with P. berghei ANKA. To assess renal function, creatinine, blood urea nitrogen, and ratio of proteinuria and creatininuria were evaluated. The products of oxidative stress, as well as cytokine profile were quantified in plasma and renal tissue. The change of renal microvascular permeability, tissue hypoxia and cellular apoptosis were also evaluated. Parasite infection resulted in renal dysfunction. Furthermore, we observed increased expression of adhesion molecule, proinflammatory cytokines and products of oxidative stress, associated with a decrease mRNA expression of HO-1 in kidney tissue of infected mice. The measurement of lipoprotein oxidizability also showed a significant increase in plasma of infected animals. Together, our findings support the idea that products of oxidative stress, as well as the immune response against the parasite are crucial to changes in kidney architecture and microvascular endothelial permeability of BALB/c mice infected with P. berghei ANKA.Rosa Maria EliasMatheus Correa-CostaClaudiene Rodrigues BarretoReinaldo Correia SilvaCaroline Y HayashidaAngela CastoldiGiselle Martins GonçalvesTarcio Teodoro BragaRenato BarbozaFrancisco José RiosAlexandre Castro KellerMarcos Antonio CenedezeMeire Ioshie HyaneMaria Regina D'Império-LimaAntônio Martins Figueiredo-NetoMarlene Antônia ReisCláudio Romero Farias MarinhoAlvaro Pacheco-SilvaNiels Olsen Saraiva CâmaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e44004 (2012) |
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Medicine R Science Q Rosa Maria Elias Matheus Correa-Costa Claudiene Rodrigues Barreto Reinaldo Correia Silva Caroline Y Hayashida Angela Castoldi Giselle Martins Gonçalves Tarcio Teodoro Braga Renato Barboza Francisco José Rios Alexandre Castro Keller Marcos Antonio Cenedeze Meire Ioshie Hyane Maria Regina D'Império-Lima Antônio Martins Figueiredo-Neto Marlene Antônia Reis Cláudio Romero Farias Marinho Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| description |
Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stress products, a characteristic of Plasmodium infection, as well as proinflammatory response induced by the parasite are involved in its pathophysiology. Therefore, we aimed to investigate the development of malaria-associated AKI during infection by P. berghei ANKA, with special attention to the role played by the inflammatory response and the involvement of oxidative stress. For that, we took advantage of an experimental model of severe malaria that showed significant changes in the renal pathophysiology to investigate the role of malaria infection in the renal microvascular permeability and tissue injury. Therefore, BALB/c mice were infected with P. berghei ANKA. To assess renal function, creatinine, blood urea nitrogen, and ratio of proteinuria and creatininuria were evaluated. The products of oxidative stress, as well as cytokine profile were quantified in plasma and renal tissue. The change of renal microvascular permeability, tissue hypoxia and cellular apoptosis were also evaluated. Parasite infection resulted in renal dysfunction. Furthermore, we observed increased expression of adhesion molecule, proinflammatory cytokines and products of oxidative stress, associated with a decrease mRNA expression of HO-1 in kidney tissue of infected mice. The measurement of lipoprotein oxidizability also showed a significant increase in plasma of infected animals. Together, our findings support the idea that products of oxidative stress, as well as the immune response against the parasite are crucial to changes in kidney architecture and microvascular endothelial permeability of BALB/c mice infected with P. berghei ANKA. |
| format |
article |
| author |
Rosa Maria Elias Matheus Correa-Costa Claudiene Rodrigues Barreto Reinaldo Correia Silva Caroline Y Hayashida Angela Castoldi Giselle Martins Gonçalves Tarcio Teodoro Braga Renato Barboza Francisco José Rios Alexandre Castro Keller Marcos Antonio Cenedeze Meire Ioshie Hyane Maria Regina D'Império-Lima Antônio Martins Figueiredo-Neto Marlene Antônia Reis Cláudio Romero Farias Marinho Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara |
| author_facet |
Rosa Maria Elias Matheus Correa-Costa Claudiene Rodrigues Barreto Reinaldo Correia Silva Caroline Y Hayashida Angela Castoldi Giselle Martins Gonçalves Tarcio Teodoro Braga Renato Barboza Francisco José Rios Alexandre Castro Keller Marcos Antonio Cenedeze Meire Ioshie Hyane Maria Regina D'Império-Lima Antônio Martins Figueiredo-Neto Marlene Antônia Reis Cláudio Romero Farias Marinho Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara |
| author_sort |
Rosa Maria Elias |
| title |
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| title_short |
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| title_full |
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| title_fullStr |
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| title_full_unstemmed |
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. |
| title_sort |
oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during p. berghei anka infection. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/ecf40e72827348b2970e39165d5ebfd2 |
| work_keys_str_mv |
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