Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

<h4>Objective</h4>Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with p...

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Autores principales:	Hugh Ramsay, Ian Kelleher, Padraig Flannery, Mary C Clarke, Fionnuala Lynch, Michelle Harley, Dearbhla Connor, Carol Fitzpatrick, Derek W Morris, Mary Cannon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ecf8625315c74cfb908654d572419928
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spelling	oai:doaj.org-article:ecf8625315c74cfb908654d5724199282021-11-18T08:48:16ZRelationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.1932-620310.1371/journal.pone.0079741https://doaj.org/article/ecf8625315c74cfb908654d5724199282013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24224001/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences.<h4>Method</h4>Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses.<h4>Results</h4>While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype.<h4>Conclusion</h4>The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.Hugh RamsayIan KelleherPadraig FlanneryMary C ClarkeFionnuala LynchMichelle HarleyDearbhla ConnorCarol FitzpatrickDerek W MorrisMary CannonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79741 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hugh Ramsay Ian Kelleher Padraig Flannery Mary C Clarke Fionnuala Lynch Michelle Harley Dearbhla Connor Carol Fitzpatrick Derek W Morris Mary Cannon Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
description	<h4>Objective</h4>Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences.<h4>Method</h4>Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses.<h4>Results</h4>While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype.<h4>Conclusion</h4>The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.
format	article
author	Hugh Ramsay Ian Kelleher Padraig Flannery Mary C Clarke Fionnuala Lynch Michelle Harley Dearbhla Connor Carol Fitzpatrick Derek W Morris Mary Cannon
author_facet	Hugh Ramsay Ian Kelleher Padraig Flannery Mary C Clarke Fionnuala Lynch Michelle Harley Dearbhla Connor Carol Fitzpatrick Derek W Morris Mary Cannon
author_sort	Hugh Ramsay
title	Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
title_short	Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
title_full	Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
title_fullStr	Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
title_full_unstemmed	Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
title_sort	relationship between the comt-val158met and bdnf-val66met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ecf8625315c74cfb908654d572419928
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Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

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