CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis

Abstract A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ping-Huai Wang, Shu-Yung Lin, Susan Shih-Jung Lee, Shu-Wen Lin, Chih-Yuan Lee, Yu-Feng Wei, Chin-Chung Shu, Jann-Yuan Wang, Chong-Jen Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ecfca8e843634ac0924fc2e3cc3157ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ecfca8e843634ac0924fc2e3cc3157ab
record_format	dspace
spelling	oai:doaj.org-article:ecfca8e843634ac0924fc2e3cc3157ab2021-12-02T16:08:58ZCD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis10.1038/s41598-020-78374-32045-2322https://doaj.org/article/ecfca8e843634ac0924fc2e3cc3157ab2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78374-3https://doaj.org/toc/2045-2322Abstract A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT0 results and conducted two rounds of follow-up paired QFT-GIT1&2 and QFT-Plus1&2 tests at an interval of 6 months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT0 results were enrolled. The baseline QFT-GIT0 response was higher in the 1st QFT-Plus1(+) group than in the QFT-Plus1(−) group, but insignificantly different between the 1st QFT-GIT1(+) and QFT-GIT1(−) groups. The two assays had good correlation when concurrently tested. Fifty-three subjects completed a second round of the QFT-GIT2 and QFT-Plus2. Persistent positivity was higher with the QFT-Plus2 (81.8%) than with the QFT-GIT2 (58.8%, p = 0.040). The QFT-GIT1 and QFT-Plus1 CD4 responses were higher in patients with persistent positivity than in those with negative reversion, whereas the difference of the QFT-Plus TB1 and TB2 data, representative of the CD8 response, were similar between positive persistence and negative reversion. In conclusion, the QFT-Plus provides more reliable positive consistency than does the QFT-GIT. The CD4 interferon-γ response might play a role in maintaining positivity of LTBI.Ping-Huai WangShu-Yung LinSusan Shih-Jung LeeShu-Wen LinChih-Yuan LeeYu-Feng WeiChin-Chung ShuJann-Yuan WangChong-Jen YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping-Huai Wang Shu-Yung Lin Susan Shih-Jung Lee Shu-Wen Lin Chih-Yuan Lee Yu-Feng Wei Chin-Chung Shu Jann-Yuan Wang Chong-Jen Yu CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
description	Abstract A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT0 results and conducted two rounds of follow-up paired QFT-GIT1&2 and QFT-Plus1&2 tests at an interval of 6 months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT0 results were enrolled. The baseline QFT-GIT0 response was higher in the 1st QFT-Plus1(+) group than in the QFT-Plus1(−) group, but insignificantly different between the 1st QFT-GIT1(+) and QFT-GIT1(−) groups. The two assays had good correlation when concurrently tested. Fifty-three subjects completed a second round of the QFT-GIT2 and QFT-Plus2. Persistent positivity was higher with the QFT-Plus2 (81.8%) than with the QFT-GIT2 (58.8%, p = 0.040). The QFT-GIT1 and QFT-Plus1 CD4 responses were higher in patients with persistent positivity than in those with negative reversion, whereas the difference of the QFT-Plus TB1 and TB2 data, representative of the CD8 response, were similar between positive persistence and negative reversion. In conclusion, the QFT-Plus provides more reliable positive consistency than does the QFT-GIT. The CD4 interferon-γ response might play a role in maintaining positivity of LTBI.
format	article
author	Ping-Huai Wang Shu-Yung Lin Susan Shih-Jung Lee Shu-Wen Lin Chih-Yuan Lee Yu-Feng Wei Chin-Chung Shu Jann-Yuan Wang Chong-Jen Yu
author_facet	Ping-Huai Wang Shu-Yung Lin Susan Shih-Jung Lee Shu-Wen Lin Chih-Yuan Lee Yu-Feng Wei Chin-Chung Shu Jann-Yuan Wang Chong-Jen Yu
author_sort	Ping-Huai Wang
title	CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
title_short	CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
title_full	CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
title_fullStr	CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
title_full_unstemmed	CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
title_sort	cd4 response of quantiferon-tb gold plus for positive consistency of latent tuberculosis infection in patients on dialysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ecfca8e843634ac0924fc2e3cc3157ab
work_keys_str_mv	AT pinghuaiwang cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT shuyunglin cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT susanshihjunglee cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT shuwenlin cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT chihyuanlee cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT yufengwei cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT chinchungshu cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT jannyuanwang cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis AT chongjenyu cd4responseofquantiferontbgoldplusforpositiveconsistencyoflatenttuberculosisinfectioninpatientsondialysis
_version_	1718384506254131200

CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis

Ejemplares similares