Differential regulation of OCT4 targets facilitates reacquisition of pluripotency

Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour durin...

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Autores principales:	Sudhir Thakurela, Camille Sindhu, Evgeny Yurkovsky, Christina Riemenschneider, Zachary D. Smith, Iftach Nachman, Alexander Meissner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecff860b9f7e4f0fa81f283c7a870aea
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spelling	oai:doaj.org-article:ecff860b9f7e4f0fa81f283c7a870aea2021-12-02T14:35:31ZDifferential regulation of OCT4 targets facilitates reacquisition of pluripotency10.1038/s41467-019-11741-52041-1723https://doaj.org/article/ecff860b9f7e4f0fa81f283c7a870aea2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11741-5https://doaj.org/toc/2041-1723Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour during differentiation.Sudhir ThakurelaCamille SindhuEvgeny YurkovskyChristina RiemenschneiderZachary D. SmithIftach NachmanAlexander MeissnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sudhir Thakurela Camille Sindhu Evgeny Yurkovsky Christina Riemenschneider Zachary D. Smith Iftach Nachman Alexander Meissner Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
description	Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour during differentiation.
format	article
author	Sudhir Thakurela Camille Sindhu Evgeny Yurkovsky Christina Riemenschneider Zachary D. Smith Iftach Nachman Alexander Meissner
author_facet	Sudhir Thakurela Camille Sindhu Evgeny Yurkovsky Christina Riemenschneider Zachary D. Smith Iftach Nachman Alexander Meissner
author_sort	Sudhir Thakurela
title	Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_short	Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_full	Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_fullStr	Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_full_unstemmed	Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_sort	differential regulation of oct4 targets facilitates reacquisition of pluripotency
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ecff860b9f7e4f0fa81f283c7a870aea
work_keys_str_mv	AT sudhirthakurela differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT camillesindhu differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT evgenyyurkovsky differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT christinariemenschneider differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT zacharydsmith differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT iftachnachman differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency AT alexandermeissner differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
_version_	1718391166785814528

Differential regulation of OCT4 targets facilitates reacquisition of pluripotency

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