Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour durin...
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Main Authors: | , , , , , , |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
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Subjects: | |
Online Access: | https://doaj.org/article/ecff860b9f7e4f0fa81f283c7a870aea |
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