Differential regulation of OCT4 targets facilitates reacquisition of pluripotency

Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour durin...

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Bibliographic Details
Main Authors: Sudhir Thakurela, Camille Sindhu, Evgeny Yurkovsky, Christina Riemenschneider, Zachary D. Smith, Iftach Nachman, Alexander Meissner
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/ecff860b9f7e4f0fa81f283c7a870aea
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