The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics

Abstract Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applica...

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Autores principales:	Javier Cruz, Klas Hjort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed03979036b44aafadfa146a3c19c8dc
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spelling	oai:doaj.org-article:ed03979036b44aafadfa146a3c19c8dc2021-12-02T16:30:47ZThe upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics10.1038/s41598-021-85910-22045-2322https://doaj.org/article/ed03979036b44aafadfa146a3c19c8dc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85910-2https://doaj.org/toc/2045-2322Abstract Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ratio Curved microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the targets in a single, stable, and high-quality position. The experiments also revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial focusing.Javier CruzKlas HjortNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Javier Cruz Klas Hjort The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
description	Abstract Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ratio Curved microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the targets in a single, stable, and high-quality position. The experiments also revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial focusing.
format	article
author	Javier Cruz Klas Hjort
author_facet	Javier Cruz Klas Hjort
author_sort	Javier Cruz
title	The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
title_short	The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
title_full	The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
title_fullStr	The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
title_full_unstemmed	The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
title_sort	upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed03979036b44aafadfa146a3c19c8dc
work_keys_str_mv	AT javiercruz theupperlimitandliftforcewithininertialfocusinginhighaspectratiocurvedmicrofluidics AT klashjort theupperlimitandliftforcewithininertialfocusinginhighaspectratiocurvedmicrofluidics AT javiercruz upperlimitandliftforcewithininertialfocusinginhighaspectratiocurvedmicrofluidics AT klashjort upperlimitandliftforcewithininertialfocusinginhighaspectratiocurvedmicrofluidics
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The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics

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