Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis

Recent evidence suggests that diet modifies key biological factors associated with the development of depression. It has been suggested that this could be due to the high flavonoid content commonly found in many plant foods, beverages and dietary supplements. Our aim was to conduct a systematic revi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sawan Ali, Graziamaria Corbi, Michael Maes, Giovanni Scapagnini, Sergio Davinelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavonoids depression antioxidants oxidative stress diet mental health Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ed0702e36446481b87bc292a0af2c9bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed0702e36446481b87bc292a0af2c9bc
record_format	dspace
spelling	oai:doaj.org-article:ed0702e36446481b87bc292a0af2c9bc2021-11-25T16:25:16ZExploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis10.3390/antiox101116442076-3921https://doaj.org/article/ed0702e36446481b87bc292a0af2c9bc2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1644https://doaj.org/toc/2076-3921Recent evidence suggests that diet modifies key biological factors associated with the development of depression. It has been suggested that this could be due to the high flavonoid content commonly found in many plant foods, beverages and dietary supplements. Our aim was to conduct a systematic review to evaluate the effects of dietary flavonoids on the symptoms of depression. A total of 46 studies met the eligibility criteria. Of these, 36 were intervention trials and 10 were observational studies. A meta-analysis of 36 clinical trials involving a total of 2788 participants was performed. The results showed a statistically significant effect of flavonoids on depressive symptoms (mean difference = −1.65; 95% C.I., −2.54, −0.77; <i>p</i> < 0.01). Five of the 10 observational studies included in the systematic review reported significant results, suggesting that a higher flavonoid intake may improve symptoms of depression. Further studies are urgently required to elucidate whether causal and mechanistic links exist, along with substantiation of functional brain changes associated with flavonoid consumption.Sawan AliGraziamaria CorbiMichael MaesGiovanni ScapagniniSergio DavinelliMDPI AGarticleflavonoidsdepressionantioxidantsoxidative stressdietmental healthTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1644, p 1644 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids depression antioxidants oxidative stress diet mental health Therapeutics. Pharmacology RM1-950
spellingShingle	flavonoids depression antioxidants oxidative stress diet mental health Therapeutics. Pharmacology RM1-950 Sawan Ali Graziamaria Corbi Michael Maes Giovanni Scapagnini Sergio Davinelli Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
description	Recent evidence suggests that diet modifies key biological factors associated with the development of depression. It has been suggested that this could be due to the high flavonoid content commonly found in many plant foods, beverages and dietary supplements. Our aim was to conduct a systematic review to evaluate the effects of dietary flavonoids on the symptoms of depression. A total of 46 studies met the eligibility criteria. Of these, 36 were intervention trials and 10 were observational studies. A meta-analysis of 36 clinical trials involving a total of 2788 participants was performed. The results showed a statistically significant effect of flavonoids on depressive symptoms (mean difference = −1.65; 95% C.I., −2.54, −0.77; <i>p</i> < 0.01). Five of the 10 observational studies included in the systematic review reported significant results, suggesting that a higher flavonoid intake may improve symptoms of depression. Further studies are urgently required to elucidate whether causal and mechanistic links exist, along with substantiation of functional brain changes associated with flavonoid consumption.
format	article
author	Sawan Ali Graziamaria Corbi Michael Maes Giovanni Scapagnini Sergio Davinelli
author_facet	Sawan Ali Graziamaria Corbi Michael Maes Giovanni Scapagnini Sergio Davinelli
author_sort	Sawan Ali
title	Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
title_short	Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
title_full	Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
title_fullStr	Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
title_full_unstemmed	Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis
title_sort	exploring the impact of flavonoids on symptoms of depression: a systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed0702e36446481b87bc292a0af2c9bc
work_keys_str_mv	AT sawanali exploringtheimpactofflavonoidsonsymptomsofdepressionasystematicreviewandmetaanalysis AT graziamariacorbi exploringtheimpactofflavonoidsonsymptomsofdepressionasystematicreviewandmetaanalysis AT michaelmaes exploringtheimpactofflavonoidsonsymptomsofdepressionasystematicreviewandmetaanalysis AT giovanniscapagnini exploringtheimpactofflavonoidsonsymptomsofdepressionasystematicreviewandmetaanalysis AT sergiodavinelli exploringtheimpactofflavonoidsonsymptomsofdepressionasystematicreviewandmetaanalysis
_version_	1718413234227118080

Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis

Ejemplares similares