The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Abstract The state of the intestinal environment can have profound effects on the activity of the central nervous system through the physiological contributions of the microbiota, regulation of intestinal barrier function, and altered activity of peripheral neurons. The common language employed for...

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Autores principales:	Madelyn C. Houser, Malú G. Tansey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ed0ba2805db348a4801acf12842d3a38
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spelling	oai:doaj.org-article:ed0ba2805db348a4801acf12842d3a382021-12-02T16:09:02ZThe gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?10.1038/s41531-016-0002-02373-8057https://doaj.org/article/ed0ba2805db348a4801acf12842d3a382017-01-01T00:00:00Zhttps://doi.org/10.1038/s41531-016-0002-0https://doaj.org/toc/2373-8057Abstract The state of the intestinal environment can have profound effects on the activity of the central nervous system through the physiological contributions of the microbiota, regulation of intestinal barrier function, and altered activity of peripheral neurons. The common language employed for much of the gut-brain communication is the modulation of immune activity. Chronic proinflammatory immune activity is increasingly being recognized as a fundamental element of neurodegenerative disorders, and in Parkinson’s disease, inflammation in the intestine appears particularly relevant in pathogenesis. We review the evidence that intestinal dysfunction is present in Parkinson’s disease and that it may reflect the earliest manifestations of Parkinson’s disease pathology, and we link these findings to dysregulated immune activity. Based on this, we present a model for Parkinson’s disease pathogenesis in which the disorder originates in the intestine and progresses with inflammation as its underlying mechanism. More in-depth investigations into the physiological mechanisms underlying peripheral pre-motor symptoms in Parkinson’s disease are expected to lead to the development of novel diagnostic and therapeutic measures that can slow or limit progression of the disease to more advanced stages involving debilitating motor and cognitive symptoms.Madelyn C. HouserMalú G. TanseyNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Madelyn C. Houser Malú G. Tansey The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
description	Abstract The state of the intestinal environment can have profound effects on the activity of the central nervous system through the physiological contributions of the microbiota, regulation of intestinal barrier function, and altered activity of peripheral neurons. The common language employed for much of the gut-brain communication is the modulation of immune activity. Chronic proinflammatory immune activity is increasingly being recognized as a fundamental element of neurodegenerative disorders, and in Parkinson’s disease, inflammation in the intestine appears particularly relevant in pathogenesis. We review the evidence that intestinal dysfunction is present in Parkinson’s disease and that it may reflect the earliest manifestations of Parkinson’s disease pathology, and we link these findings to dysregulated immune activity. Based on this, we present a model for Parkinson’s disease pathogenesis in which the disorder originates in the intestine and progresses with inflammation as its underlying mechanism. More in-depth investigations into the physiological mechanisms underlying peripheral pre-motor symptoms in Parkinson’s disease are expected to lead to the development of novel diagnostic and therapeutic measures that can slow or limit progression of the disease to more advanced stages involving debilitating motor and cognitive symptoms.
format	article
author	Madelyn C. Houser Malú G. Tansey
author_facet	Madelyn C. Houser Malú G. Tansey
author_sort	Madelyn C. Houser
title	The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
title_short	The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
title_full	The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
title_fullStr	The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
title_full_unstemmed	The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
title_sort	gut-brain axis: is intestinal inflammation a silent driver of parkinson’s disease pathogenesis?
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed0ba2805db348a4801acf12842d3a38
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The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

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