A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

HECT type E3 ligases are key regulators of cell growth and proliferation. Here the authors present the crystal structures of the Nedd4 family E3 ligase WWP1 in a closed and semi-open state and in combination with mutagenesis experiments identify a multi-lock regulatory mechanism that allows the fine...

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Auteurs principaux:	Zhen Wang, Ziheng Liu, Xing Chen, Jingyu Li, Weiyi Yao, Shijing Huang, Aihong Gu, Qun-Ying Lei, Ying Mao, Wenyu Wen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ed0c3c09d75e424cad3894422e8ab3e0
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spelling	oai:doaj.org-article:ed0c3c09d75e424cad3894422e8ab3e02021-12-02T17:02:17ZA multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases10.1038/s41467-019-11224-72041-1723https://doaj.org/article/ed0c3c09d75e424cad3894422e8ab3e02019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11224-7https://doaj.org/toc/2041-1723HECT type E3 ligases are key regulators of cell growth and proliferation. Here the authors present the crystal structures of the Nedd4 family E3 ligase WWP1 in a closed and semi-open state and in combination with mutagenesis experiments identify a multi-lock regulatory mechanism that allows the fine-tuning of activities of Nedd4 family E3 ligases.Zhen WangZiheng LiuXing ChenJingyu LiWeiyi YaoShijing HuangAihong GuQun-Ying LeiYing MaoWenyu WenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen Wang Ziheng Liu Xing Chen Jingyu Li Weiyi Yao Shijing Huang Aihong Gu Qun-Ying Lei Ying Mao Wenyu Wen A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
description	HECT type E3 ligases are key regulators of cell growth and proliferation. Here the authors present the crystal structures of the Nedd4 family E3 ligase WWP1 in a closed and semi-open state and in combination with mutagenesis experiments identify a multi-lock regulatory mechanism that allows the fine-tuning of activities of Nedd4 family E3 ligases.
format	article
author	Zhen Wang Ziheng Liu Xing Chen Jingyu Li Weiyi Yao Shijing Huang Aihong Gu Qun-Ying Lei Ying Mao Wenyu Wen
author_facet	Zhen Wang Ziheng Liu Xing Chen Jingyu Li Weiyi Yao Shijing Huang Aihong Gu Qun-Ying Lei Ying Mao Wenyu Wen
author_sort	Zhen Wang
title	A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
title_short	A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
title_full	A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
title_fullStr	A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
title_full_unstemmed	A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
title_sort	multi-lock inhibitory mechanism for fine-tuning enzyme activities of the hect family e3 ligases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ed0c3c09d75e424cad3894422e8ab3e0
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A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

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