Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis

Kaname Ueda,1 Tomoyuki Takura,2 Shinji Fujikoshi,1 Juliana Meyers,3 Saurabh P Nagar,3 Hiroyuki Enomoto1 1Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Department of Healthcare Economics and Health Policy, University of Tokyo, Tokyo, Japan; 3RTI Health Solutions, Research Tria...

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Autores principales:	Ueda K, Takura T, Fujikoshi S, Meyers J, Nagar SP, Enomoto H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	knee osteoarthritis pain management japan working-aged hcru Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ed0ee7aa84b940d3a37fe139329bc146
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spelling	oai:doaj.org-article:ed0ee7aa84b940d3a37fe139329bc1462021-12-02T11:10:08ZLongitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis1178-1998https://doaj.org/article/ed0ee7aa84b940d3a37fe139329bc1462020-06-01T00:00:00Zhttps://www.dovepress.com/longitudinal-assessment-of-pain-management-among-the-employed-japanese-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Kaname Ueda,1 Tomoyuki Takura,2 Shinji Fujikoshi,1 Juliana Meyers,3 Saurabh P Nagar,3 Hiroyuki Enomoto1 1Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Department of Healthcare Economics and Health Policy, University of Tokyo, Tokyo, Japan; 3RTI Health Solutions, Research Triangle Park, NC, USACorrespondence: Kaname UedaMedicines Development Unit Japan, Eli Lilly Japan K.K., 5-1-28 Isogamidori, Chuo-ku, Kobe 651-0086, JapanTel +81-78-242-9519Fax +81-78-242-9939Email ueda_kaname@lilly.comPurpose: To assess comorbidity burden and pain-management patterns among working-aged patients with knee osteoarthritis only (KOA/O) and patients with knee osteoarthritis plus osteoarthritis at another site (KOA/+) in Japan.Patients and Methods: Retrospective claims data analysis was conducted using the Japan Medical Data Center database. Working-aged adults (aged 40 to 71 years) with 5 years of follow-up and diagnosed with knee osteoarthritis (KOA) between January 1, 2011, and December 31, 2012, were evaluated. The first claim with a KOA diagnosis defined the index date. Patients were divided into two mutually exclusive cohorts: KOA/O and KOA/+. Longitudinal pain-management patterns during each year of follow-up were analyzed.Results: A total of 2542 patients met study criteria: 1575 KOA/O and 967 KOA/+. Mean age and number of comorbidities were higher among the KOA/+ versus KOA/O cohort. Pharmaceutical treatment was received by 91.5% of patients in the KOA/+ compared with 85.1% of patients in the KOA/O cohort during the first year of follow-up. The most common pharmacological treatment received during the first year of follow-up was either topical or oral nonsteroidal anti-inflammatory drugs for both cohorts. During each year of follow-up, the KOA/+ cohort had greater proportion of patients with at least one health-care encounter (ie, hospital admissions, outpatient and pharmacy visits) and higher direct medical costs compared with the KOA/O cohort.Conclusion: This study demonstrates that a greater proportion of the working population with KOA/+ received pain-related treatment compared with patients with KOA/O. Further studies are necessary to evaluate appropriate pain management for both KOA only and KOA with other sites.Keywords: knee osteoarthritis, pain management, Japan, working-aged, HCRUUeda KTakura TFujikoshi SMeyers JNagar SPEnomoto HDove Medical Pressarticleknee osteoarthritispain managementjapanworking-agedhcruGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1003-1012 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	knee osteoarthritis pain management japan working-aged hcru Geriatrics RC952-954.6
spellingShingle	knee osteoarthritis pain management japan working-aged hcru Geriatrics RC952-954.6 Ueda K Takura T Fujikoshi S Meyers J Nagar SP Enomoto H Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
description	Kaname Ueda,1 Tomoyuki Takura,2 Shinji Fujikoshi,1 Juliana Meyers,3 Saurabh P Nagar,3 Hiroyuki Enomoto1 1Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Department of Healthcare Economics and Health Policy, University of Tokyo, Tokyo, Japan; 3RTI Health Solutions, Research Triangle Park, NC, USACorrespondence: Kaname UedaMedicines Development Unit Japan, Eli Lilly Japan K.K., 5-1-28 Isogamidori, Chuo-ku, Kobe 651-0086, JapanTel +81-78-242-9519Fax +81-78-242-9939Email ueda_kaname@lilly.comPurpose: To assess comorbidity burden and pain-management patterns among working-aged patients with knee osteoarthritis only (KOA/O) and patients with knee osteoarthritis plus osteoarthritis at another site (KOA/+) in Japan.Patients and Methods: Retrospective claims data analysis was conducted using the Japan Medical Data Center database. Working-aged adults (aged 40 to 71 years) with 5 years of follow-up and diagnosed with knee osteoarthritis (KOA) between January 1, 2011, and December 31, 2012, were evaluated. The first claim with a KOA diagnosis defined the index date. Patients were divided into two mutually exclusive cohorts: KOA/O and KOA/+. Longitudinal pain-management patterns during each year of follow-up were analyzed.Results: A total of 2542 patients met study criteria: 1575 KOA/O and 967 KOA/+. Mean age and number of comorbidities were higher among the KOA/+ versus KOA/O cohort. Pharmaceutical treatment was received by 91.5% of patients in the KOA/+ compared with 85.1% of patients in the KOA/O cohort during the first year of follow-up. The most common pharmacological treatment received during the first year of follow-up was either topical or oral nonsteroidal anti-inflammatory drugs for both cohorts. During each year of follow-up, the KOA/+ cohort had greater proportion of patients with at least one health-care encounter (ie, hospital admissions, outpatient and pharmacy visits) and higher direct medical costs compared with the KOA/O cohort.Conclusion: This study demonstrates that a greater proportion of the working population with KOA/+ received pain-related treatment compared with patients with KOA/O. Further studies are necessary to evaluate appropriate pain management for both KOA only and KOA with other sites.Keywords: knee osteoarthritis, pain management, Japan, working-aged, HCRU
format	article
author	Ueda K Takura T Fujikoshi S Meyers J Nagar SP Enomoto H
author_facet	Ueda K Takura T Fujikoshi S Meyers J Nagar SP Enomoto H
author_sort	Ueda K
title	Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
title_short	Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
title_full	Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
title_fullStr	Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
title_full_unstemmed	Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis
title_sort	longitudinal assessment of pain management among the employed japanese population with knee osteoarthritis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ed0ee7aa84b940d3a37fe139329bc146
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Longitudinal Assessment of Pain Management Among the Employed Japanese Population with Knee Osteoarthritis

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