Update of the global distribution of human gammaherpesvirus 8 genotypes

Abstract Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic sequence of the open reading frame (ORF)-K1. There are a few conflicting reports regarding the global distribution of the different HHV-8 genotypes. This study aimed to determine the global distribution...

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Autores principales:	Amanda de Oliveira Lopes, Natália Spitz, Christian Robson de Souza Reis, Vanessa Salete de Paula
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed108e51c8754bce9c06bf89a622dbd4
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spelling	oai:doaj.org-article:ed108e51c8754bce9c06bf89a622dbd42021-12-02T14:37:21ZUpdate of the global distribution of human gammaherpesvirus 8 genotypes10.1038/s41598-021-87038-92045-2322https://doaj.org/article/ed108e51c8754bce9c06bf89a622dbd42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87038-9https://doaj.org/toc/2045-2322Abstract Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic sequence of the open reading frame (ORF)-K1. There are a few conflicting reports regarding the global distribution of the different HHV-8 genotypes. This study aimed to determine the global distribution of the different HHV-8 genotypes based on phylogenetic analysis of the ORF-K1 coding region using sequences published in the GenBank during 1997–2020 and construct a phylogenetic tree using the maximum likelihood algorithm with the GTR + I + G nucleotide substitution model. A total of 550 sequences from 38 countries/origins were analysed in this study. Genotypes A and C had similar global distributions and were prevalent in Africa and Europe. Genotype B was prevalent in Africa. Of the rare genotypes, genotype D was reported in East Asia and Oceania and genotype E in South America, while genotype F was prevalent in Africa. The highest genotypic diversity was reported in the American continent, with Brazil housing five HHV-8 genotypes (A, B, C, E, and F). In this study, we present update of the global distribution of HHV-8 genotypes, providing a basis for future epidemiological and evolutionary studies of HHV-8.Amanda de Oliveira LopesNatália SpitzChristian Robson de Souza ReisVanessa Salete de PaulaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amanda de Oliveira Lopes Natália Spitz Christian Robson de Souza Reis Vanessa Salete de Paula Update of the global distribution of human gammaherpesvirus 8 genotypes
description	Abstract Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic sequence of the open reading frame (ORF)-K1. There are a few conflicting reports regarding the global distribution of the different HHV-8 genotypes. This study aimed to determine the global distribution of the different HHV-8 genotypes based on phylogenetic analysis of the ORF-K1 coding region using sequences published in the GenBank during 1997–2020 and construct a phylogenetic tree using the maximum likelihood algorithm with the GTR + I + G nucleotide substitution model. A total of 550 sequences from 38 countries/origins were analysed in this study. Genotypes A and C had similar global distributions and were prevalent in Africa and Europe. Genotype B was prevalent in Africa. Of the rare genotypes, genotype D was reported in East Asia and Oceania and genotype E in South America, while genotype F was prevalent in Africa. The highest genotypic diversity was reported in the American continent, with Brazil housing five HHV-8 genotypes (A, B, C, E, and F). In this study, we present update of the global distribution of HHV-8 genotypes, providing a basis for future epidemiological and evolutionary studies of HHV-8.
format	article
author	Amanda de Oliveira Lopes Natália Spitz Christian Robson de Souza Reis Vanessa Salete de Paula
author_facet	Amanda de Oliveira Lopes Natália Spitz Christian Robson de Souza Reis Vanessa Salete de Paula
author_sort	Amanda de Oliveira Lopes
title	Update of the global distribution of human gammaherpesvirus 8 genotypes
title_short	Update of the global distribution of human gammaherpesvirus 8 genotypes
title_full	Update of the global distribution of human gammaherpesvirus 8 genotypes
title_fullStr	Update of the global distribution of human gammaherpesvirus 8 genotypes
title_full_unstemmed	Update of the global distribution of human gammaherpesvirus 8 genotypes
title_sort	update of the global distribution of human gammaherpesvirus 8 genotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed108e51c8754bce9c06bf89a622dbd4
work_keys_str_mv	AT amandadeoliveiralopes updateoftheglobaldistributionofhumangammaherpesvirus8genotypes AT nataliaspitz updateoftheglobaldistributionofhumangammaherpesvirus8genotypes AT christianrobsondesouzareis updateoftheglobaldistributionofhumangammaherpesvirus8genotypes AT vanessasaletedepaula updateoftheglobaldistributionofhumangammaherpesvirus8genotypes
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Update of the global distribution of human gammaherpesvirus 8 genotypes

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