The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia

Abstract To explore the clinical application value of chest CT quantitative pulmonary inflammation index (PII) in the evaluation of the course and treatment outcome of COVID-19 pneumonia. One hundred and eighteen patients with COVID-19 pneumonia diagnosed by RT-PCR were analyzed retrospectively. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song Peng, Jinqing Chen, Wendy Zhang, Bangjun Zhang, Zhifeng Liu, Lang Liu, Zhaofeng Wu, Rui Fu, Xiuhua Li, Fajin Lv
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed13a7cab2224c21beb6005880535ce6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed13a7cab2224c21beb6005880535ce6
record_format	dspace
spelling	oai:doaj.org-article:ed13a7cab2224c21beb6005880535ce62021-12-02T14:21:21ZThe role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia10.1038/s41598-021-87430-52045-2322https://doaj.org/article/ed13a7cab2224c21beb6005880535ce62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87430-5https://doaj.org/toc/2045-2322Abstract To explore the clinical application value of chest CT quantitative pulmonary inflammation index (PII) in the evaluation of the course and treatment outcome of COVID-19 pneumonia. One hundred and eighteen patients with COVID-19 pneumonia diagnosed by RT-PCR were analyzed retrospectively. The correlation between chest CT PII, clinical symptoms and laboratory examinations during the entire hospitalization period was compared. The average age of the patients was 46.0 ± 15 (range: 1–74) years. Of the 118 patients, 62 are male (52.5%) and 56 are female (47.5%). Among them, 116 patients recovered and were discharged, 2 patients died, and the median length of hospital stay was 22 (range: 9–41) days. On admission, 76.3% of the patients presented with fever, and the laboratory studies showed a decrease in lymphocyte (LYM) count and an increase in lactate dehydrogenase (LDH) levels, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR). Within the studies’ chest CTs, the median number of involved lung lobes was 4 (range: 0–5) and the median number of involved lung segments was 9 (range 0–20). The left lower lobe and the right lower lobe were the most likely areas to be involved (89.0% and 83.9%), and 84.7% of the patients had inflammatory changes in both lungs. The main manifestations on chest CT were ground glass opacities (31.4%), ground glass opacities and consolidation (20.3%), ground glass opacities and reticular patterns (32.2%), mixed type (13.6%), and white lungs (1.7%); common accompanying signs included linear opacities (55.9%), air bronchograms (46.6%), thick small vessel shadows (36.4%), and pleural hypertrophy (13.6%). The chest CT at discharge showed complete absorption of lesions in 19 cases (16.1%), but not in the remaining 99 cases. Lesions remained in a median of 3 lung lobes (range: 0–5). Residual lesions remained in a median of 5 lung segments (range: 0–20). The residual lesions mainly presented as ground glass opacities (61.0%), and the main accompanying sign was linear opacities (59.3%). Based on chest CT, the median maximum PII of lungs was 30.0% (range: 0–97.5%), and the median PII after discharge in the patients excluding the two deaths was 12.5% (range: 0–53.0%). PII was significantly negatively correlated with the LYM count and significantly positively correlated with body temperature, LDH, CRP, and ESR. There was no significant correlation between the PII and the white blood cell count, but the grade of PII correlated well with the clinical classification. PII can be used to monitor the severity and the treatment outcome of COVID-19 pneumonia, provide help for clinical classification, assist in treatment plan adjustments and aid assessments for discharge.Song PengJinqing ChenWendy ZhangBangjun ZhangZhifeng LiuLang LiuZhaofeng WuRui FuXiuhua LiFajin LvNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Song Peng Jinqing Chen Wendy Zhang Bangjun Zhang Zhifeng Liu Lang Liu Zhaofeng Wu Rui Fu Xiuhua Li Fajin Lv The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
description	Abstract To explore the clinical application value of chest CT quantitative pulmonary inflammation index (PII) in the evaluation of the course and treatment outcome of COVID-19 pneumonia. One hundred and eighteen patients with COVID-19 pneumonia diagnosed by RT-PCR were analyzed retrospectively. The correlation between chest CT PII, clinical symptoms and laboratory examinations during the entire hospitalization period was compared. The average age of the patients was 46.0 ± 15 (range: 1–74) years. Of the 118 patients, 62 are male (52.5%) and 56 are female (47.5%). Among them, 116 patients recovered and were discharged, 2 patients died, and the median length of hospital stay was 22 (range: 9–41) days. On admission, 76.3% of the patients presented with fever, and the laboratory studies showed a decrease in lymphocyte (LYM) count and an increase in lactate dehydrogenase (LDH) levels, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR). Within the studies’ chest CTs, the median number of involved lung lobes was 4 (range: 0–5) and the median number of involved lung segments was 9 (range 0–20). The left lower lobe and the right lower lobe were the most likely areas to be involved (89.0% and 83.9%), and 84.7% of the patients had inflammatory changes in both lungs. The main manifestations on chest CT were ground glass opacities (31.4%), ground glass opacities and consolidation (20.3%), ground glass opacities and reticular patterns (32.2%), mixed type (13.6%), and white lungs (1.7%); common accompanying signs included linear opacities (55.9%), air bronchograms (46.6%), thick small vessel shadows (36.4%), and pleural hypertrophy (13.6%). The chest CT at discharge showed complete absorption of lesions in 19 cases (16.1%), but not in the remaining 99 cases. Lesions remained in a median of 3 lung lobes (range: 0–5). Residual lesions remained in a median of 5 lung segments (range: 0–20). The residual lesions mainly presented as ground glass opacities (61.0%), and the main accompanying sign was linear opacities (59.3%). Based on chest CT, the median maximum PII of lungs was 30.0% (range: 0–97.5%), and the median PII after discharge in the patients excluding the two deaths was 12.5% (range: 0–53.0%). PII was significantly negatively correlated with the LYM count and significantly positively correlated with body temperature, LDH, CRP, and ESR. There was no significant correlation between the PII and the white blood cell count, but the grade of PII correlated well with the clinical classification. PII can be used to monitor the severity and the treatment outcome of COVID-19 pneumonia, provide help for clinical classification, assist in treatment plan adjustments and aid assessments for discharge.
format	article
author	Song Peng Jinqing Chen Wendy Zhang Bangjun Zhang Zhifeng Liu Lang Liu Zhaofeng Wu Rui Fu Xiuhua Li Fajin Lv
author_facet	Song Peng Jinqing Chen Wendy Zhang Bangjun Zhang Zhifeng Liu Lang Liu Zhaofeng Wu Rui Fu Xiuhua Li Fajin Lv
author_sort	Song Peng
title	The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
title_short	The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
title_full	The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
title_fullStr	The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
title_full_unstemmed	The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
title_sort	role of chest ct quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of covid-19 pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed13a7cab2224c21beb6005880535ce6
work_keys_str_mv	AT songpeng theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT jinqingchen theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT wendyzhang theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT bangjunzhang theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT zhifengliu theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT langliu theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT zhaofengwu theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT ruifu theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT xiuhuali theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT fajinlv theroleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT songpeng roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT jinqingchen roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT wendyzhang roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT bangjunzhang roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT zhifengliu roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT langliu roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT zhaofengwu roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT ruifu roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT xiuhuali roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia AT fajinlv roleofchestctquantitativepulmonaryinflammatoryindexintheevaluationofthecourseandtreatmentoutcomeofcovid19pneumonia
_version_	1718391581037297664

The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia

Ejemplares similares