Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.

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Autores principales: Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu, Zhiwei Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/ed18969fb27e4c749a94ac8b64c9a7f7
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spelling oai:doaj.org-article:ed18969fb27e4c749a94ac8b64c9a7f72021-12-02T17:33:05ZDeficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection10.1038/s41467-018-05746-92041-1723https://doaj.org/article/ed18969fb27e4c749a94ac8b64c9a7f72018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05746-9https://doaj.org/toc/2041-1723SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.Peixin SongNan ZhengYong LiuChen TianXilin WuXiaohua MaDeyan ChenXue ZouGuiyang WangHuanru WangYongyang ZhangSufang LuChao WuZhiwei WuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peixin Song
Nan Zheng
Yong Liu
Chen Tian
Xilin Wu
Xiaohua Ma
Deyan Chen
Xue Zou
Guiyang Wang
Huanru Wang
Yongyang Zhang
Sufang Lu
Chao Wu
Zhiwei Wu
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
description SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.
format article
author Peixin Song
Nan Zheng
Yong Liu
Chen Tian
Xilin Wu
Xiaohua Ma
Deyan Chen
Xue Zou
Guiyang Wang
Huanru Wang
Yongyang Zhang
Sufang Lu
Chao Wu
Zhiwei Wu
author_facet Peixin Song
Nan Zheng
Yong Liu
Chen Tian
Xilin Wu
Xiaohua Ma
Deyan Chen
Xue Zou
Guiyang Wang
Huanru Wang
Yongyang Zhang
Sufang Lu
Chao Wu
Zhiwei Wu
author_sort Peixin Song
title Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_short Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_full Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_fullStr Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_full_unstemmed Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_sort deficient humoral responses and disrupted b-cell immunity are associated with fatal sftsv infection
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ed18969fb27e4c749a94ac8b64c9a7f7
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AT nanzheng deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
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AT chentian deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT xilinwu deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT xiaohuama deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT deyanchen deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT xuezou deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT guiyangwang deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT huanruwang deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT yongyangzhang deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT sufanglu deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT chaowu deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
AT zhiweiwu deficienthumoralresponsesanddisruptedbcellimmunityareassociatedwithfatalsftsvinfection
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