Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact

Abstract Coronavirus with intact infectivity attached to PPE surfaces pose significant threat to the spread of COVID-19. We tested the hypothesis that an electroceutical fabric, generating weak potential difference of 0.5 V, disrupts the infectivity of coronavirus upon contact by destabilizing the e...

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Autores principales:	Subhadip Ghatak, Dolly K. Khona, Abhishek Sen, Kaixiang Huang, Gargi Jagdale, Kanhaiya Singh, Vinoj Gopalakrishnan, Kenneth G. Cornetta, Sashwati Roy, Savita Khanna, Lane A. Baker, Chandan K. Sen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed1b5fdb21524735a1607c65ef78afd2
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spelling	oai:doaj.org-article:ed1b5fdb21524735a1607c65ef78afd22021-11-08T10:55:13ZElectroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact10.1038/s41598-021-00910-62045-2322https://doaj.org/article/ed1b5fdb21524735a1607c65ef78afd22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00910-6https://doaj.org/toc/2045-2322Abstract Coronavirus with intact infectivity attached to PPE surfaces pose significant threat to the spread of COVID-19. We tested the hypothesis that an electroceutical fabric, generating weak potential difference of 0.5 V, disrupts the infectivity of coronavirus upon contact by destabilizing the electrokinetic properties of the virion. Porcine respiratory coronavirus AR310 particles (105) were placed in direct contact with the fabric for 1 or 5 min. Following one minute of contact, zeta potential of the porcine coronavirus was significantly lowered indicating destabilization of its electrokinetic properties. Size-distribution plot showed appearance of aggregation of the virus. Testing of the cytopathic effects of the virus showed eradication of infectivity as quantitatively assessed by PI-calcein and MTT cell viability tests. This work provides the rationale to consider the studied electroceutical fabric, or other materials with comparable property, as material of choice for the development of PPE in the fight against COVID-19.Subhadip GhatakDolly K. KhonaAbhishek SenKaixiang HuangGargi JagdaleKanhaiya SinghVinoj GopalakrishnanKenneth G. CornettaSashwati RoySavita KhannaLane A. BakerChandan K. SenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Subhadip Ghatak Dolly K. Khona Abhishek Sen Kaixiang Huang Gargi Jagdale Kanhaiya Singh Vinoj Gopalakrishnan Kenneth G. Cornetta Sashwati Roy Savita Khanna Lane A. Baker Chandan K. Sen Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
description	Abstract Coronavirus with intact infectivity attached to PPE surfaces pose significant threat to the spread of COVID-19. We tested the hypothesis that an electroceutical fabric, generating weak potential difference of 0.5 V, disrupts the infectivity of coronavirus upon contact by destabilizing the electrokinetic properties of the virion. Porcine respiratory coronavirus AR310 particles (105) were placed in direct contact with the fabric for 1 or 5 min. Following one minute of contact, zeta potential of the porcine coronavirus was significantly lowered indicating destabilization of its electrokinetic properties. Size-distribution plot showed appearance of aggregation of the virus. Testing of the cytopathic effects of the virus showed eradication of infectivity as quantitatively assessed by PI-calcein and MTT cell viability tests. This work provides the rationale to consider the studied electroceutical fabric, or other materials with comparable property, as material of choice for the development of PPE in the fight against COVID-19.
format	article
author	Subhadip Ghatak Dolly K. Khona Abhishek Sen Kaixiang Huang Gargi Jagdale Kanhaiya Singh Vinoj Gopalakrishnan Kenneth G. Cornetta Sashwati Roy Savita Khanna Lane A. Baker Chandan K. Sen
author_facet	Subhadip Ghatak Dolly K. Khona Abhishek Sen Kaixiang Huang Gargi Jagdale Kanhaiya Singh Vinoj Gopalakrishnan Kenneth G. Cornetta Sashwati Roy Savita Khanna Lane A. Baker Chandan K. Sen
author_sort	Subhadip Ghatak
title	Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
title_short	Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
title_full	Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
title_fullStr	Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
title_full_unstemmed	Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
title_sort	electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed1b5fdb21524735a1607c65ef78afd2
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Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact

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