Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors

Trans-arterial radioembolization (TARE) is increasingly evaluated for unresectable intrahepatic cholangiocarcinoma (ICC). Not all ICC patients benefit equally well from TARE. Therefore, we sought to evaluate variables predicting progression-free survival (PFS) and overall survival (OS). Patients wit...

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Autores principales:	Karolin J. Paprottka, Franziska Galiè, Michael Ingrisch, Tobias Geith, Harun Ilhan, Andrei Todica, Marlies Michl, Jonathan Nadjiri, Philipp M. Paprottka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	intrahepatic cholangiocarcinoma radioembolization survival outcome safety repetitive TARE Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ed1e62634d93433c978ca4012cbc1d5c
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spelling	oai:doaj.org-article:ed1e62634d93433c978ca4012cbc1d5c2021-11-11T15:30:08ZOutcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors10.3390/cancers132153992072-6694https://doaj.org/article/ed1e62634d93433c978ca4012cbc1d5c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5399https://doaj.org/toc/2072-6694Trans-arterial radioembolization (TARE) is increasingly evaluated for unresectable intrahepatic cholangiocarcinoma (ICC). Not all ICC patients benefit equally well from TARE. Therefore, we sought to evaluate variables predicting progression-free survival (PFS) and overall survival (OS). Patients with non-resectable ICC underwent TARE and were treated with 90Y resin microspheres. Baseline characteristics, biochemical/clinical toxicities, and response were examined for impact on PFS and OS. A total of 103 treatments were administered to 73 patients without major complications or toxicity. Mean OS was 18.9 months (95% confidence intervals (CI); 13.9–23.9 months). Mean and median PFS were 10.1 months (95% CI; 7.9–12.2) and 6.4 months (95% CI; 5.20–7.61), respectively. Median OS and PFS were significantly prolonged in patients with baseline cholinesterase (CHE) ≥ 4.62 kU/L (OS: 14.0 vs. 5.5 months; PFS: 6.9 vs. 3.2 months; <i>p</i> < 0.001). Patients with a tumor burden ≤ 25% had a significantly longer OS (15.2 vs. 6.6 months; <i>p</i> = 0.036). Median PFS was significantly longer for patients with multiple TARE cycles (24.4 vs. 5.8 months; <i>p</i> = 0.04). TARE is a considerable and safe option for unresectable ICC. CA-19-9, CHE, and tumor burden have predictive value for survival in patients treated with TARE. Multiple TARE treatments might further improve survival; this has to be confirmed by further studies.Karolin J. PaprottkaFranziska GalièMichael IngrischTobias GeithHarun IlhanAndrei TodicaMarlies MichlJonathan NadjiriPhilipp M. PaprottkaMDPI AGarticleintrahepatic cholangiocarcinomaradioembolizationsurvivaloutcomesafetyrepetitive TARENeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5399, p 5399 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intrahepatic cholangiocarcinoma radioembolization survival outcome safety repetitive TARE Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	intrahepatic cholangiocarcinoma radioembolization survival outcome safety repetitive TARE Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Karolin J. Paprottka Franziska Galiè Michael Ingrisch Tobias Geith Harun Ilhan Andrei Todica Marlies Michl Jonathan Nadjiri Philipp M. Paprottka Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
description	Trans-arterial radioembolization (TARE) is increasingly evaluated for unresectable intrahepatic cholangiocarcinoma (ICC). Not all ICC patients benefit equally well from TARE. Therefore, we sought to evaluate variables predicting progression-free survival (PFS) and overall survival (OS). Patients with non-resectable ICC underwent TARE and were treated with 90Y resin microspheres. Baseline characteristics, biochemical/clinical toxicities, and response were examined for impact on PFS and OS. A total of 103 treatments were administered to 73 patients without major complications or toxicity. Mean OS was 18.9 months (95% confidence intervals (CI); 13.9–23.9 months). Mean and median PFS were 10.1 months (95% CI; 7.9–12.2) and 6.4 months (95% CI; 5.20–7.61), respectively. Median OS and PFS were significantly prolonged in patients with baseline cholinesterase (CHE) ≥ 4.62 kU/L (OS: 14.0 vs. 5.5 months; PFS: 6.9 vs. 3.2 months; <i>p</i> < 0.001). Patients with a tumor burden ≤ 25% had a significantly longer OS (15.2 vs. 6.6 months; <i>p</i> = 0.036). Median PFS was significantly longer for patients with multiple TARE cycles (24.4 vs. 5.8 months; <i>p</i> = 0.04). TARE is a considerable and safe option for unresectable ICC. CA-19-9, CHE, and tumor burden have predictive value for survival in patients treated with TARE. Multiple TARE treatments might further improve survival; this has to be confirmed by further studies.
format	article
author	Karolin J. Paprottka Franziska Galiè Michael Ingrisch Tobias Geith Harun Ilhan Andrei Todica Marlies Michl Jonathan Nadjiri Philipp M. Paprottka
author_facet	Karolin J. Paprottka Franziska Galiè Michael Ingrisch Tobias Geith Harun Ilhan Andrei Todica Marlies Michl Jonathan Nadjiri Philipp M. Paprottka
author_sort	Karolin J. Paprottka
title	Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
title_short	Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
title_full	Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
title_fullStr	Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
title_full_unstemmed	Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors
title_sort	outcome and safety after 103 radioembolizations with yttrium-90 resin microspheres in 73 patients with unresectable intrahepatic cholangiocarcinoma—an evaluation of predictors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed1e62634d93433c978ca4012cbc1d5c
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Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma—An Evaluation of Predictors

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