In vivo exploration of synaptic projections in frontotemporal dementia
Abstract The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections...
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Nature Portfolio
2021
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oai:doaj.org-article:ed2445097c37402c917fbae2b0ec07802021-12-02T18:50:53ZIn vivo exploration of synaptic projections in frontotemporal dementia10.1038/s41598-021-95499-12045-2322https://doaj.org/article/ed2445097c37402c917fbae2b0ec07802021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95499-1https://doaj.org/toc/2045-2322Abstract The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.Eric SalmonMohamed Ali BahriAlain PlenevauxGuillaume BeckerAlain SeretEmma DelhayeChristian DegueldreEvelyne BalteauChristian LemaireAndré LuxenChristine BastinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Eric Salmon Mohamed Ali Bahri Alain Plenevaux Guillaume Becker Alain Seret Emma Delhaye Christian Degueldre Evelyne Balteau Christian Lemaire André Luxen Christine Bastin In vivo exploration of synaptic projections in frontotemporal dementia |
| description |
Abstract The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes. |
| format |
article |
| author |
Eric Salmon Mohamed Ali Bahri Alain Plenevaux Guillaume Becker Alain Seret Emma Delhaye Christian Degueldre Evelyne Balteau Christian Lemaire André Luxen Christine Bastin |
| author_facet |
Eric Salmon Mohamed Ali Bahri Alain Plenevaux Guillaume Becker Alain Seret Emma Delhaye Christian Degueldre Evelyne Balteau Christian Lemaire André Luxen Christine Bastin |
| author_sort |
Eric Salmon |
| title |
In vivo exploration of synaptic projections in frontotemporal dementia |
| title_short |
In vivo exploration of synaptic projections in frontotemporal dementia |
| title_full |
In vivo exploration of synaptic projections in frontotemporal dementia |
| title_fullStr |
In vivo exploration of synaptic projections in frontotemporal dementia |
| title_full_unstemmed |
In vivo exploration of synaptic projections in frontotemporal dementia |
| title_sort |
in vivo exploration of synaptic projections in frontotemporal dementia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed2445097c37402c917fbae2b0ec0780 |
| work_keys_str_mv |
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