Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain

Abstract Background Alzheimer’s disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IHT) on cognitive functions in a mouse model...

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Autores principales: Xiangpei Yue, Yanzhao Zhou, Meng Qiao, Xingnan Zhao, Xin Huang, Tong Zhao, Xiang Cheng, Ming Fan, Yongqi Zhao, Ruoli Chen, Lingling Zhu
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Alzheimer’s disease
APPswe/PS1dE9 mice
Intermittent hypoxia treatment
Amyloid beta
BACE1
Neuroinflammation
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/ed26adcda63d4b01a593c7eb25408643
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