OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS

Abstract.The aim of present study was complex evaluation and analysis of hormone and immune profiles in the patients with subclinical and manifesting thyroid hypofunction, taking into account a therapeutic drug monitoring for optimization of levothyroxine treatment. Forty patients with thyroid hypof...

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Autores principales:	I. V. Sarvilina, E. F. Shin, Yu. V. Gorshkova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	treatment thyroid hypofunction levothyroxine pharmacokinetics Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ed282777a73248ba8e44273faab825e1
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spelling	oai:doaj.org-article:ed282777a73248ba8e44273faab825e12021-11-18T08:03:42ZOPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS1563-06252313-741X10.15789/1563-0625-2006-5-6-697-706https://doaj.org/article/ed282777a73248ba8e44273faab825e12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/576https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract.The aim of present study was complex evaluation and analysis of hormone and immune profiles in the patients with subclinical and manifesting thyroid hypofunction, taking into account a therapeutic drug monitoring for optimization of levothyroxine treatment. Forty patients with thyroid hypofunction are included into the study: I group, patients with subclinical hypothyreosis (n=19) and the levels of thyroxine-binding globuline exceeding 700 nmol/l, who received levothyroxine at 50 μg daily after withdrawal of drugs for 10 days; II group, the patients with manifesting hypothyreosis (n=21), who received levothyroxine at 100 μg daily. A significant regress of clinical signs of hypothyreosis was registered in both groups following 3 months of receiving levothyroxine, employing an optimized mode of dosage. An immune/endocrine component is shown for the mechanism of levothyroxine action, which promotes the development of maximal hormonal effect, with respect to improvement of life quality in the patients with hypothyreosis upon optimization of therapy based on the therapeutic drug monitoring using liquid chromatography/mass-spectrometry.I. V. SarvilinaE. F. ShinYu. V. GorshkovaSPb RAACIarticletreatmentthyroid hypofunctionlevothyroxinepharmacokineticsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 697-706 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	treatment thyroid hypofunction levothyroxine pharmacokinetics Immunologic diseases. Allergy RC581-607
spellingShingle	treatment thyroid hypofunction levothyroxine pharmacokinetics Immunologic diseases. Allergy RC581-607 I. V. Sarvilina E. F. Shin Yu. V. Gorshkova OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
description	Abstract.The aim of present study was complex evaluation and analysis of hormone and immune profiles in the patients with subclinical and manifesting thyroid hypofunction, taking into account a therapeutic drug monitoring for optimization of levothyroxine treatment. Forty patients with thyroid hypofunction are included into the study: I group, patients with subclinical hypothyreosis (n=19) and the levels of thyroxine-binding globuline exceeding 700 nmol/l, who received levothyroxine at 50 μg daily after withdrawal of drugs for 10 days; II group, the patients with manifesting hypothyreosis (n=21), who received levothyroxine at 100 μg daily. A significant regress of clinical signs of hypothyreosis was registered in both groups following 3 months of receiving levothyroxine, employing an optimized mode of dosage. An immune/endocrine component is shown for the mechanism of levothyroxine action, which promotes the development of maximal hormonal effect, with respect to improvement of life quality in the patients with hypothyreosis upon optimization of therapy based on the therapeutic drug monitoring using liquid chromatography/mass-spectrometry.
format	article
author	I. V. Sarvilina E. F. Shin Yu. V. Gorshkova
author_facet	I. V. Sarvilina E. F. Shin Yu. V. Gorshkova
author_sort	I. V. Sarvilina
title	OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
title_short	OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
title_full	OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
title_fullStr	OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
title_full_unstemmed	OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS
title_sort	optimization of levothyroxine therapy based upon complex evaluation of hormonal and immune status in the patients with sub-clinical and manifesting hypothyreosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ed282777a73248ba8e44273faab825e1
work_keys_str_mv	AT ivsarvilina optimizationoflevothyroxinetherapybaseduponcomplexevaluationofhormonalandimmunestatusinthepatientswithsubclinicalandmanifestinghypothyreosis AT efshin optimizationoflevothyroxinetherapybaseduponcomplexevaluationofhormonalandimmunestatusinthepatientswithsubclinicalandmanifestinghypothyreosis AT yuvgorshkova optimizationoflevothyroxinetherapybaseduponcomplexevaluationofhormonalandimmunestatusinthepatientswithsubclinicalandmanifestinghypothyreosis
_version_	1718422515697582080

OPTIMIZATION OF LEVOTHYROXINE THERAPY BASED UPON COMPLEX EVALUATION OF HORMONAL AND IMMUNE STATUS IN THE PATIENTS WITH SUB-CLINICAL AND MANIFESTING HYPOTHYREOSIS

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