Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

Abstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between thes...

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Autores principales:	Daniel Gomes de Almeida-Filho, Bruna Del Vechio Koike, Francesca Billwiller, Kelly Soares Farias, Igor Rafael Praxedes de Sales, Pierre-Hervé Luppi, Sidarta Ribeiro, Claudio Marcos Queiroz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed298cbeaf4e4392add1a42be5f98fa9
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spelling	oai:doaj.org-article:ed298cbeaf4e4392add1a42be5f98fa92021-12-02T16:05:55ZHippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation10.1038/s41598-021-91659-52045-2322https://doaj.org/article/ed298cbeaf4e4392add1a42be5f98fa92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91659-5https://doaj.org/toc/2045-2322Abstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon.Daniel Gomes de Almeida-FilhoBruna Del Vechio KoikeFrancesca BillwillerKelly Soares FariasIgor Rafael Praxedes de SalesPierre-Hervé LuppiSidarta RibeiroClaudio Marcos QueirozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
description	Abstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon.
format	article
author	Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz
author_facet	Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz
author_sort	Daniel Gomes de Almeida-Filho
title	Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_short	Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_full	Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_fullStr	Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_full_unstemmed	Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_sort	hippocampus-retrosplenial cortex interaction is increased during phasic rem and contributes to memory consolidation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed298cbeaf4e4392add1a42be5f98fa9
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Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

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