Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cos...

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Autores principales:	Gholamhossein Sodeifian, Seyed Ali Sajadian, Fariba Razmimanesh, Seyed Mojtaba Hazaveie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed2a24a11e1d4d9197f0fa3fd43ae43c
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spelling	oai:doaj.org-article:ed2a24a11e1d4d9197f0fa3fd43ae43c2021-12-02T14:37:39ZSolubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations10.1038/s41598-021-87243-62045-2322https://doaj.org/article/ed2a24a11e1d4d9197f0fa3fd43ae43c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87243-6https://doaj.org/toc/2045-2322Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 0.20 × 10–6 and 8.02 × 10–5, while drug solubility in the SC-CO2 with cosolvent varied from 1.2 × 10–5 to 1.96 × 10–4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD% = 6.45, R adj = 0.995.Gholamhossein SodeifianSeyed Ali SajadianFariba RazmimaneshSeyed Mojtaba HazaveieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gholamhossein Sodeifian Seyed Ali Sajadian Fariba Razmimanesh Seyed Mojtaba Hazaveie Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
description	Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 0.20 × 10–6 and 8.02 × 10–5, while drug solubility in the SC-CO2 with cosolvent varied from 1.2 × 10–5 to 1.96 × 10–4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD% = 6.45, R adj = 0.995.
format	article
author	Gholamhossein Sodeifian Seyed Ali Sajadian Fariba Razmimanesh Seyed Mojtaba Hazaveie
author_facet	Gholamhossein Sodeifian Seyed Ali Sajadian Fariba Razmimanesh Seyed Mojtaba Hazaveie
author_sort	Gholamhossein Sodeifian
title	Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
title_short	Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
title_full	Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
title_fullStr	Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
title_full_unstemmed	Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations
title_sort	solubility of ketoconazole (antifungal drug) in sc-co2 for binary and ternary systems: measurements and empirical correlations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed2a24a11e1d4d9197f0fa3fd43ae43c
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Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

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