Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy

TLR4 agonists have been proposed as immunotherapeutics in cancer. Here, the authors show the TLR4-dependent adjuvant effect of FimH, an E. coli adhesin, in promoting dendritic cell mediated-T cell activation and response to immune checkpoint blockade in preclinical cancer models.

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Autores principales:	Wei Zhang, Li Xu, Hae-Bin Park, Juyoung Hwang, Minseok Kwak, Peter C. W. Lee, Guang Liang, Xiaoyan Zhang, Jianqing Xu, Jun-O Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed2a29d550e746acad1fd481acb4d24e
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spelling	oai:doaj.org-article:ed2a29d550e746acad1fd481acb4d24e2021-12-02T14:41:14ZEscherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy10.1038/s41467-020-15030-42041-1723https://doaj.org/article/ed2a29d550e746acad1fd481acb4d24e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15030-4https://doaj.org/toc/2041-1723TLR4 agonists have been proposed as immunotherapeutics in cancer. Here, the authors show the TLR4-dependent adjuvant effect of FimH, an E. coli adhesin, in promoting dendritic cell mediated-T cell activation and response to immune checkpoint blockade in preclinical cancer models.Wei ZhangLi XuHae-Bin ParkJuyoung HwangMinseok KwakPeter C. W. LeeGuang LiangXiaoyan ZhangJianqing XuJun-O JinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Zhang Li Xu Hae-Bin Park Juyoung Hwang Minseok Kwak Peter C. W. Lee Guang Liang Xiaoyan Zhang Jianqing Xu Jun-O Jin Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
description	TLR4 agonists have been proposed as immunotherapeutics in cancer. Here, the authors show the TLR4-dependent adjuvant effect of FimH, an E. coli adhesin, in promoting dendritic cell mediated-T cell activation and response to immune checkpoint blockade in preclinical cancer models.
format	article
author	Wei Zhang Li Xu Hae-Bin Park Juyoung Hwang Minseok Kwak Peter C. W. Lee Guang Liang Xiaoyan Zhang Jianqing Xu Jun-O Jin
author_facet	Wei Zhang Li Xu Hae-Bin Park Juyoung Hwang Minseok Kwak Peter C. W. Lee Guang Liang Xiaoyan Zhang Jianqing Xu Jun-O Jin
author_sort	Wei Zhang
title	Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
title_short	Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
title_full	Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
title_fullStr	Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
title_full_unstemmed	Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy
title_sort	escherichia coli adhesion portion fimh functions as an adjuvant for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ed2a29d550e746acad1fd481acb4d24e
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Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy

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