Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats
Abstract Background This study investigates the segmental myocardial strain of the early phase of intramyocardial hemorrhage (IMH) caused by reperfused myocardial infarction (MI) in rats by low-dose dobutamine (LDD) cardiovascular magnetic resonance (CMR) feature-tracking. Methods Nine sham rats and...
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2021
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oai:doaj.org-article:ed2ad2ffd6a048c0b35b9a03f56531c62021-11-21T12:33:33ZLow-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats10.1186/s12880-021-00709-x1471-2342https://doaj.org/article/ed2ad2ffd6a048c0b35b9a03f56531c62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00709-xhttps://doaj.org/toc/1471-2342Abstract Background This study investigates the segmental myocardial strain of the early phase of intramyocardial hemorrhage (IMH) caused by reperfused myocardial infarction (MI) in rats by low-dose dobutamine (LDD) cardiovascular magnetic resonance (CMR) feature-tracking. Methods Nine sham rats and nine rats with 60-min myocardial ischemia followed by 48-h reperfusion were investigated using CMR, including T2*-mapping sequence and fast imaging with steady-state precession (FISP)–cine sequence. Another FISP–cine sequence was acquired after 2 min of dobutamine injection; the MI, IMH, and Non-MI (NMI) areas were identified. The values of peak radial strains (PRS) and peak circumferential strains (PCS) of the MI, IMH and NMI segments were acquired. The efficiency of PRS and PCS (EPRS and EPCS, respectively) were calculated on the basis of the time of every single heartbeat. Results The PRS, PCS, EPRS, and EPCS of the sham group increased after LDD injection. However, the PRS, PCS, EPRS, and EPCS of the IMH segment did not increase. Moreover, the PRS and PCS of the MI and NMI segments did not increase, but the EPRS and EPCS of these segments increased. The PRS, PCS, EPRS, and EPCS of the IMH segment were lower than those of the MI and NMI segments before and after LDD injection, but without a significant difference between MI segment and NMI segment before and after LDD injection. Conclusions LDD could help assess dysfunctions in segments with IMH, especially using the efficiency of strain. IMH was a crucial factor that decreased segmental movement and reserved function.Rui XiaBo HeTong ZhuYu ZhangYushu ChenLei WangYang ZhouJichun LiaoJie ZhengYongmei LiFajin LvFabao GaoBMCarticleMyocardial infarctionReperfusionMagnetic resonance imagingDobutamineMedical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-7 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Myocardial infarction Reperfusion Magnetic resonance imaging Dobutamine Medical technology R855-855.5 |
| spellingShingle |
Myocardial infarction Reperfusion Magnetic resonance imaging Dobutamine Medical technology R855-855.5 Rui Xia Bo He Tong Zhu Yu Zhang Yushu Chen Lei Wang Yang Zhou Jichun Liao Jie Zheng Yongmei Li Fajin Lv Fabao Gao Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| description |
Abstract Background This study investigates the segmental myocardial strain of the early phase of intramyocardial hemorrhage (IMH) caused by reperfused myocardial infarction (MI) in rats by low-dose dobutamine (LDD) cardiovascular magnetic resonance (CMR) feature-tracking. Methods Nine sham rats and nine rats with 60-min myocardial ischemia followed by 48-h reperfusion were investigated using CMR, including T2*-mapping sequence and fast imaging with steady-state precession (FISP)–cine sequence. Another FISP–cine sequence was acquired after 2 min of dobutamine injection; the MI, IMH, and Non-MI (NMI) areas were identified. The values of peak radial strains (PRS) and peak circumferential strains (PCS) of the MI, IMH and NMI segments were acquired. The efficiency of PRS and PCS (EPRS and EPCS, respectively) were calculated on the basis of the time of every single heartbeat. Results The PRS, PCS, EPRS, and EPCS of the sham group increased after LDD injection. However, the PRS, PCS, EPRS, and EPCS of the IMH segment did not increase. Moreover, the PRS and PCS of the MI and NMI segments did not increase, but the EPRS and EPCS of these segments increased. The PRS, PCS, EPRS, and EPCS of the IMH segment were lower than those of the MI and NMI segments before and after LDD injection, but without a significant difference between MI segment and NMI segment before and after LDD injection. Conclusions LDD could help assess dysfunctions in segments with IMH, especially using the efficiency of strain. IMH was a crucial factor that decreased segmental movement and reserved function. |
| format |
article |
| author |
Rui Xia Bo He Tong Zhu Yu Zhang Yushu Chen Lei Wang Yang Zhou Jichun Liao Jie Zheng Yongmei Li Fajin Lv Fabao Gao |
| author_facet |
Rui Xia Bo He Tong Zhu Yu Zhang Yushu Chen Lei Wang Yang Zhou Jichun Liao Jie Zheng Yongmei Li Fajin Lv Fabao Gao |
| author_sort |
Rui Xia |
| title |
Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| title_short |
Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| title_full |
Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| title_fullStr |
Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| title_full_unstemmed |
Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| title_sort |
low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed2ad2ffd6a048c0b35b9a03f56531c6 |
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